50-23-7 |
| 时间：2023-07-15 来源：化工号 作者：C21H30O5 |
| 中文名 | 氢化可的松
| | 英文名 | Hydrocortisone
| | 别名 | 皮质甾醇
氢化皮质素
氢化可的松
氢化皮质酮
皮质醇 溶液
氢化可的松溶液,100PPM
11β,17α,21-三羟基孕甾-4-烯-3,20-二酮
皮质甾醇,氢化皮质素,氢化皮质酮,17-羟基皮质(甾)酮,可的索
| | 英文别名 | cortisol
Cortanal
Hydrocortisone
compoundf(kendall)
Hydrocortisone Base
HYDROCORTISONE MICRONIZED
Prednisolone EP Impurity A
21-Trihydroxypregn-4-ene-3
Hydrocortisone Acetate Impurity?A
Hydrocortisone, Chromatographic Standard
11,17,21-trihydroxypregn-4-ene-3,20-dione
11,17a,21-Trihydroxy-4-pragnene-3,20-dione
(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
11beta,17alpha,21-Trihydroxypregn-4-ene-3,20-dione
11-beta,17-alpha,21-trihydroxypregn-4-ene-3,20-dione
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
| | CAS | 50-23-7
| | EINECS | 200-020-1 | | 化学式 | C21H30O5
| | 分子量 | 362.47 | | InChI | InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15+,16+,18+,19+,20-,21+/m1/s1 | | 密度 | 1.0812 (rough estimate) | | 熔点 | 211-214°C(lit.) | | 沸点 | 414.06°C (rough estimate) | | 比旋光度 | 166 º (c=1, C2H5OH 25 ºC) | | 闪点 | 220°C | | 水溶性 | 319.7mg/L(25 ºC) | | 蒸汽压 | 3.44E-15mmHg at 25°C | | 溶解度 | H2O: 100mg/mL | | 折射率 | 1.6120 (estimate) | | 存储条件 | -20°C | | 稳定性 | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. | | 敏感性 | Sensitive to light | | 外观 | powder | | 颜色 | White | | Merck | 14,4787 | | BRN | 1354819 | | 物化性质 | 白色或类白色结晶性粉末，无臭，味苦。遇光变质。Mp214-220℃(分解)；比旋光度[α]25D+157.5°(二噁烷)、+176°(氯仿)、+162°-+169°(乙醇)；乙醇溶液在242nm波长处有最大吸收。本品不溶于水，难溶于乙醚，微溶于氯仿，溶于丙酮、乙醇。可溶于浓硫酸液并呈绿色荧光。LD50 (大鼠，腹腔)150mg/kg。 | | 产品用途 | 为肾上腺皮质激素类药 | | MDL号 | MFCD00011654 | | 危险品标志 | Xn - 有害物品
| | 风险术语 | R62 - 有损害生育能力的危险。
R63 - 可能有对胎儿造成伤害的危险。
| | 安全术语 | 36/37 - 穿戴适当的防护服和手套。
| | WGK Germany | 3 | | RTECS | GM8925000 | | TSCA | Yes | | 海关编号 | 29372100 | | 上游原料 | 醋酸异丙酯 氨基脲 醋酸可的松 皂素 脱氧可的松 | | 下游产品 | 丙酸地泼罗酮 21-乙酰氧基-6Α,9Α-二氟-11Β,16Α,17Α,三羟基孕甾-1,4-二烯-3,20-二酮 21-乙酰氧基-9Α-氟-11Β,16Α,17Α-三羟基孕甾-1,4-二烯-3,20-二酮 泼尼松 孕甾-3,5,9(11)-三烯-3Β,17Α,21-三醇-20-酮-3,17,21-三醋酸酯 泼尼松龙 醋酸阿奈可他 醋酸氢化可的松 21-乙酰氧基-9Β,11Β-环氧-17Α-羟基孕甾-4-烯-3,20-二酮 孕甾-4,9(11)-二烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 9Β,11Β-环氧孕甾-4-烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 21-乙酰氧基-9Α-溴-11Β,17Α-二羟基孕甾-4-烯-3,20-二酮 9Α-溴孕甾-4-烯-11Β,17Α,21-三醇-3,20-二酮-17,21-二醋酸酯 6Β-氟孕甾-4,9(11)-二烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 | | 参考资料 展开查看 | 1. 陈青青,单超文,苏洁,陈炜,朱加明,陈素红,吕圭源.无比山药丸对氢化可的松致肾阳虚模型小鼠性功能的影响[J].浙江大学学报(医学版),2020,49(06):697-704.
2. 杜攀攀,李木清,毛滔,刘梨,程学荣,杨振武,姜雄.象皮生肌膏对慢性创面模型大鼠血清β-EP、PGE_2和5-HT表达的影响[J].中医药导报,2020,26(16):31-34+44.
3. Chen, Jing, et al. "Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone." Metabolic engineering 57 (2020): 31-42.https://do
4. [IF=9.783] Jing Chen et al."Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone."Metab Eng. 2020 Jan;57:31
5. [IF=7.086] Gaopan Dong et al."Zebrafish neuro-behavioral profiles altered by acesulfame (ACE) within the range of “no observed effect concentrations (NOECs)”."Chemosphere. 2020 Mar;243:125431
6. [IF=4.813] Chen Jing et al."Production of 14α-hydroxysteroids by a recombinant Saccharomyces cerevisiae biocatalyst expressing of a fungal steroid 14α-hydroxylation system."Appl Microbiol Biot. 2019 Oct;103(20):8363-8374
7. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513
8. [IF=5.279] Xiang Li et al."Zebrafish Behavioral Phenomics Links Artificial Sweetener Aspartame to Behavioral Toxicity and Neurotransmitter Homeostasis."J Agr Food Chem. 2021;69(50):15393–15402 |
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