叶酸 |
| 时间：2023-07-15 来源：化工号 作者：C19H19N7O6 |
| 中文名 | 叶酸
| | 英文名 | Folic acid
| | 别名 | 叶酸
维生素M
维生素Bc
叶酸水合物
维生素 M
叶酸(蝶酰谷氨酸)
叶酸 59-30-3
叶酸溶液, 100PPM
叶酸(维生素B9)食品级
N-[4-(2-氨基-4-氧化-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸
N-[4-(2-氨基-4-氧代-6-蝶啶)甲氨基苯甲酰基]-L-谷氨酸
N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸
N-(4-((2-氨基-4-氧代-1,4-二氢-6-蝶啶)甲氨基)苯甲酰基)-L-谷氨酸
(2S)-2-[[4-[(2-氨基-4-氧代-1H-蝶啶-6-基)甲基氨基]苯甲酰]氨基]戊二酸二水合物
| | 英文别名 | PGA
pteglu
folbal
PTEGLU
folsav
cytofol
folacin
folacid
foluite
folipac
foliamin
folettes
acifolic
millafol
folsaure
incafolic
Vitamin B
Vitamin M
Folic acid
Vitamin BC
folcysteine
Vitamin B11
PTEROYGLUTAMIC ACID
PTEROYLGLUTAMIC ACID
L-pteroylglutamic acid
PTEROYL-L-GLUTAMIC ACID
pteroyl-L-glutamic acid
PTEROYLMONOGLUTAMIC ACID
pteroylmonoglutamic acid
EZNA KIT FUNGAL DNA MINI
KIT BLOOD DNA EZNA 5 TESTS
pteroyl-L-monoglutamic acid
4-(2-amino-4-oxopteridin-6-yl) methylaminobenzoyl-L-glutamic acid
N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID
2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridinol
N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-4-[(2-Amido-4-oxo-1,4-dihydro-6-terene) methyl amino] benzoyl-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
(2R)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate
| | CAS | 59-30-3
| | EINECS | 200-419-0 | | 化学式 | C19H19N7O6
| | 分子量 | 441.4 | | InChI | InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/p-2/t12-/m1/s1 | | InChIKey | OVBPIULPVIDEAO-LBPRGKRZSA-N | | 密度 | 1.4704 (rough estimate) | | 熔点 | 250 °C | | 沸点 | 552.35°C (rough estimate) | | 比旋光度 | 20 º (c=1, 0.1N NaOH) | | 水溶性 | 1.6 mg/L (25 ºC) | | 溶解度 | boiling water: soluble1% | | 折射率 | 1.6800 (estimate) | | 酸度系数 | pKa 2.5 (Uncertain) | | 存储条件 | 2-8°C | | 稳定性 | Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive. | | 敏感性 | Sensitive to light | | 外观 | Crystalline Powder | | 颜色 | Yellow to orange | | 气味 | Odorless | | Merck | 14,4221 | | BRN | 100781 | | 物化性质 | 橙色针状结晶。无熔点，250℃炭化。对可见光稳定，见紫外光活性降低，酸、碱加速氧化水解。比旋光度[α]25D+23°(0.5%，0.1mol/L 氢氧化钠液)。本品的0.1mol/L NaOH溶液，在256nm、283nm、365nm波长处有最大吸收。不溶于水、乙醇、乙醚和氯仿，微溶于甲醇，溶于醋酸、吡啶、氢氧化碱和碳酸碱溶液。LD50 (大鼠，静脉) 500 mg/kg。 | | 产品用途 | 抗贫血药，用于症状性或营养性巨细胞型贫血症。 | | MDL号 | MFCD00079305 | | 风险术语 | R33 - 有累积效应的危险品。
R62 - 有损害生育能力的危险。
R68 - 可能有不可逆后果的危险。
| | 安全术语 | 24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 1 | | RTECS | LP5425000 | | FLUKA BRAND F CODES | 8 | | TSCA | Yes | | 海关编号 | 29362900 | | 上游原料 | 焦亚硫酸钠 2,4,5-三氨基-6-羟基嘧啶硫酸盐 对氨基苯甲酰谷氨酸 桔红 1,1,3-三氯丙酮 | | 下游产品 | 蝶呤-6-羧酸 DL-焦谷氨酸 四氢叶酸 | | 参考资料 展开查看 | 1. 张珍明 陈达 谭超兰 等. 一锅煮法合成5-甲基四氢叶酸钙[J]. 淮海工学院学报:自然科学版 2018 27(04):47-51.
2. 商迎辉,刘馨君,黄汉昌,劳凤学.婴幼儿乳品中叶酸的微生物测定方法[J].食品与生物技术学报,2018,37(07):727-731.
3. 张健,商迎辉,李棠,刘冬颖.洋鸡蛋与柴鸡蛋蛋黄中叶酸含量的比较[J].北京联合大学学报(自然科学版),2014,28(03):29-32.
4. 王梦, 张加玲. 荧光法测定果蔬中叶酸含量的研究[J]. 中国食物与营养, 2016, 22(03):40-42.
5. 邢志华, 方桂珍, 苏玲,等. 羟基喜树碱叶酸-壳聚糖纳米粒的制备及其性能研究[J]. 功能材料, 2012, 43(B11):322-325.
6. 陈银彬 王玉芳 侯志芳 等. Rg1联合B族维生素对急性心肌缺血小鼠NO释放及Rg1入脑量的影响[J]. 特产研究 2016(1):5-8.
7. 郭刚军, 胡小静, 徐荣,等. 干燥方式对辣木叶营养,功能成分及氨基酸组成的影响[J]. 食品科学, 2018, 39(011):39-45.
8. 汪凯. 口服次血红素六肽改善2型糖尿病肝脏胰岛素抵抗的机制研究[D].吉林大学,2020.
9. Mengsi Li, Caixia Wang, Liming Chen, Defang Liu,A novel electrochemiluminescence sensor based on resonance energy transfer system between nitrogen doped graphene quantum dots and boron nitride quantum dots for sensitive detection of folic acid,Analytica
10. Chen, Yin Bin, et al. "Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration." Journal of ginseng research 41.2 (2017): 209-214.https://doi.org/10.1016/j.jgr.2016.03.006
11. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https://doi.org/10.1039/D0RA08689D
12. [IF=6.06] Yin Bin Chen et al."Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration."J Ginseng Res. 2017 Apr;41:209
13. [IF=2.786] Peihe Zheng et al."Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration."J Med Food. 2017 Nov;20(11):1127-1132
14. [IF=9.381] Qian Du et al."A multiple environment-sensitive prodrug nanomicelle strategy based on chitosan graftomer for enhanced tumor therapy of gambogic acid."Carbohyd Polym. 2021 Sep;267:118229
15. [IF=6.558] Mengsi Li et al."A novel electrochemiluminescence sensor based on resonance energy transfer system between nitrogen doped graphene quantum dots and boron nitride quantum dots for sensitive detection of folic acid."Anal Chim Acta. 2019 Dec;1090:57
16. [IF=3.981] Wenhui Gao et al."Preparation and evaluation of folate-decorated human serum albumin nanoparticles for the targeted delivery of sorafenib to enhance antihepatocarcinoma efficacy."J Drug Deliv Sci Tec. 2019 Dec;54:101349
17. [IF=4.384] Xuena Li et al."Methotrexate-loaded folic acid of solid-phase synthesis conjugated gold nanoparticles targeted treatment for rheumatoid arthritis."Eur J Pharm Sci. 2022 Mar;170:106101
18. [IF=2.391] Wu Zhihao et al."Preparation of Monascus-fermented ginkgo seeds: optimization of fermentation parameters and evaluation of bioactivity."FOOD SCIENCE AND BIOTECHNOLOGY. 2022 Apr;:1-10 |
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