N-乙酰半胱氨酸 |
| 时间：2023-07-15 来源：化工号 作者：C5H9NO3S |
| 中文名 | N-乙酰半胱氨酸
| | 英文名 | N-Acetyl-L-cysteine
| | 别名 | 易咳净
乙酰半胱氨酸
N-乙酰半胱氨酸
N-乙酰-L-半胱氨酸
N-乙酰基-L-半胱氨酸
N-乙酰-3-巯基丙氨酸
N-乙酰基-L-半胱氨酸辣
L-Α-乙酰氨基-Β-巯基丙酸
N-乙酰-L-半胱氨酸(+4℃)
| | 英文别名 | NAC
Tixair
Brunac
Inspir
Mucret
Fabrol
Fluatox
Airbron
Mucosol
Mucosil
Parvolex
Mucomyst
Respaire
Ac-Cys-OH
Fluimucil
Mucolator
Mucocedyl
Fluprowit
Mucosolvin
AC-L-CYS-OH
Mucolyticum
Fluimucetin
Muco Sanigen
Broncholysin
Neo-Fluimucil
Acetylcysteine
Mercapturic acid
N-acetylcysteine
N-ACETYL CYSTEINE
N-Acetyl Cysteine
N-Acetyl-cysteine
RARECHEM BK PT 0097
N-ACETYL-L-CYSTEINE
N-Acetyl-L-cysteine
N-ACETYL-L-(+)-CYSTEINE
N-acetyl-L-(+)-cysteine
N-ALPHA-ACETYL-L-CYSTEINE
N-ACETYL-3-MERCAPTOALANINE
N-acetyl-3-mercaptoalanine
(2R)-2-(acetylamino)-3-sulfanylpropanoate
(S)-ALPHA-AMINO-2-NAPHTHALENEPROPIONIC ACID
L-alpha-acetamido-beta-mercaptopropionic acid
| | CAS | 616-91-1
| | EINECS | 210-498-3 | | 化学式 | C5H9NO3S
| | 分子量 | 163.19 | | InChI | InChI=1/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/p-1/t4-/m0/s1 | | InChIKey | PWKSKIMOESPYIA-BYPYZUCNSA-N | | 密度 | 1.249 (estimate) | | 熔点 | 106-108°C(lit.) | | 沸点 | 407.7±40.0 °C(Predicted) | | 比旋光度 | -35.1 ºC (c=2,H2O) | | 闪点 | 200.4°C | | 水溶性 | Soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether. | | 蒸汽压 | 0Pa at 20℃ | | 溶解度 | H2O: 100mg/mL with heating | | 折射率 | 24 ° (C=JPC Method) | | 酸度系数 | pK1: 9.52 (30°C) | | 存储条件 | 2-8°C | | 稳定性 | Stable. Incompatible with strong oxidizing agents. | | 外观 | Solid | | 颜色 | White | | Merck | 14,88 | | BRN | 1724426 | | 物化性质 | N-乙酰-L-半胱氨酸白色结晶性粉末，有类似蒜的气味，味酸。有吸湿性，易溶于水或乙醇，不溶于乙醚、氯仿。在水溶液中呈酸性 (10g/L H2O中pH2-2.75)，mp101-107℃。本品为半胱氨酸的N-乙酰化衍生物，分子中含有巯基，能使黏蛋白肽键的二硫键(-S-S-)断裂，从而使黏蛋白链变成小分子肽链，降低粘蛋白的黏滞性，因此本品为黏痰、脓性痰、呼吸道黏液的溶解药。 | | 产品用途 | 本品仅供科研，不得用于其它用途。 | | MDL号 | MFCD00004880 | | 靶点 | ROS/ROS1 TNF-α | | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S22 - 切勿吸入粉尘。
S24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 3 | | RTECS | HA1660000 | | FLUKA BRAND F CODES | 10-23 | | TSCA | Yes | | 海关编号 | 29309016 | | 上游原料 | 三氯甲烷 药用乙醇 | | 参考资料 展开查看 | 1. 蔺良才, 赵菲菲, 王敏,等. 蓑衣莲酮硫酸酯对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J]. 天然产物研究与开发, 2018(5).
2. 成柯, 闫俊, 严晓雪,等. 湖北地区不同品种蓝莓果汁加工品质特征及抗氧化活性评价[J]. 食品与发酵工业, 2020, 046(009):146-151.
3. 王晓杰,吾买尔江·牙合甫,阿丽米热·买买提,韩俊成,杨莉,夏利宁,赛福丁·阿不拉,卡哈尔·司马义.菊苣多糖对小鼠药物性肝损伤保护作用的筛选[J].现代畜牧兽医,2021(04):9-13.
4. 邹思,易骏,吴岩斌,吴锦忠,吴建国.菌核侧耳菌核水提物对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J].食用菌学报,2020,27(04):85-90.
5. Guizi Peng, Xin Pan, Haiyan Hu, Yuehong Xu, Chuanbin Wu, N-terminal site-specific PEGylation enhances the circulation half-life of Thymosin alpha 1, Journal of Drug Delivery Science and Technology, Volume 49, 2019, Pages 405-412, ISSN 1773-2247, https://do
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12. [IF=3.361] Bingchen Han et al."The fluorescence mechanism of carbon dots based on the separation and identification of small molecular fluorophores."RSC Advances. 2022 Apr;12(19):11640-11648 |
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