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68-19-9

时间：2023-07-15 来源：化工号作者：C₆₃H₈₈CoN₁₄O₁₄P

氰钴胺

氰钻胺素

中文名	维生素B12
英文名	Vitamin B12
别名	氰钴胺氰钻胺素维生素B12 维生素 B12 钴胺素,氰钴胺维生素B12原料药维生素B12, 氰钴胺 Α-5,6-二甲基-苯并咪唑氰钴胺
英文别名	VB12 hemomin hepagon hepavis macrabin hepcovite lldfactor hepacon-b12 Vitamin B12 Cyanocobalamin lactobacilluslactisdornerfactor cyano-5,6-dimethylbenzimidazole-cobalamin 5,6-dimethyl-1-(3-o-phosphono-alpha-d-ribofuranosyl)-1h-benzimidazolmonoes
CAS	68-19-9
EINECS	200-680-0
化学式	C63H88CoN14O14P
分子量	1355.37
InChI	InChI=1/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31?,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1/rC63H89CoN14O14P/c1-30-20-40-41(21-31(30)2)77(29-73-40)58-53(87)54(42(27-79)90-58)92-93(88,89)91-32(3)26-72-50(86)18-19-60(8)38(22-47(69)83)57-63(11)62(10,25-49(71)85)37(14-17-46(68)82)52(78(63)64-28-65)34(5)56-61(9,24-48(70)84)35(12-15-44(66)80)39(74-56)23-43-59(6,7)36(13-16-45(67)81)51(75-43)33(4)55(60)76-57/h20-21,23,29,32,35-38,42,53-54,57-58,79,87H,12-19,22,24-27H2,1-11H3,(H2,66,80)(H2,67,81)(H2,68,82)(H2,69,83)(H2,70,84)(H2,71,85)(H,72,86)(H,88,89)/q+1/p-1/b39-23+,51-33-,52-34-/t32?,35-,36-,37-,38+,42-,53-,54-,57-,58+,60-,61+,62+,63+/m1/s1
InChIKey	RMRCNWBMXRMIRW-WZHZPDAFSA-L
熔点	>300°C
沸点	>300 °C
比旋光度	23656 -59 ± 9° (dil aq soln)
闪点	9℃
水溶性	Soluble
溶解度	Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic.
酸度系数	pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain)
存储条件	2-8°C
稳定性	Hygroscopic. Keep cold and dry.
敏感性	Hygroscopic
外观	Crystalline Powder or Crystals
颜色	Red to dark red
Merck	14,10014
BRN	4122889
暴露限值	NIOSH: IDLH 25 mg/m3
物化性质	深红色结晶或无定形结晶性粉末，无臭无味。熔点210～220℃(碳化变黑)。1g本品可溶于80mL水，溶于乙醇，不溶于丙酮、乙醚或氯仿。无水物易吸潮，结晶性氰钴胺在中性和微酸性溶液中对空气和热稳定性较好，在碱性、强酸及还原剂中不太稳定，不耐光和紫外线。
产品用途	主要用于治疗巨幼红细胞贫血、营养性不良、失血性贫血、神经痛及障碍性疾患
MDL号	MFCD00151092
安全术语	S24/25 - 避免与皮肤和眼睛接触。
上游原料	氯化钴氧化铅放线菌弱酸性丙烯酸系阳离子交换树脂
下游产品	甲钴胺
参考资料展开查看	1. 韩龙, 阮国祥, 马杰希,等. 维生素B12生产菌的化学诱变和抗生素抗性筛选[J]. 精细与专用化学品, 2019, 27(01):40-43. 2. 陈银彬王玉芳侯志芳等. Rg1联合B族维生素对急性心肌缺血小鼠NO释放及Rg1入脑量的影响[J]. 特产研究 2016(1):5-8. 3. Chen, Yin Bin, et al. "Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration." Journal of ginseng research 41.2 (2017): 209-214.https://doi.org/10.1016/j.jgr.2016.03.006 4. Li, Qingsi, et al. "Hemocompatible hemoadsorbent for effective removal of protein-bound toxin in serum." Journal of colloid and interface science 555 (2019): 145-156.https://doi.org/10.1016/j.jcis.2019.07.045 5. Xu, L., W. X. Cai, and B. J. Xu. "A systematic assesment on vitamins (B2, B12) and GABA profiles in fermented soy products marketed in China." Journal of Food Processing and Preservation 41.5 (2017): e13126. 6. Zheng, Peihe, et al. "Influence of B-complex vitamins on the pharmacokinetics of ginsenosides Rg1, Rb1, and Ro after oral administration." Journal of medicinal food 20.11 (2017): 1127-1132.https://doi.org/10.1089/jmf.2017.3922 7. [IF=6.06] Yin Bin Chen et al."Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration."J Ginseng Res. 2017 Apr;41:209 8. [IF=2.786] Peihe Zheng et al."Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration."J Med Food. 2017 Nov;20(11):1127-1132 9. [IF=2.19] L. Xu et al."A Systematic Assesment on Vitamins (B2, B12) and GABA Profiles in Fermented Soy Products Marketed in China."J Food Process Pres. 2017 Oct;41(5):e13126

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