68-19-9 |
| 时间：2023-07-15 来源：化工号 作者：C63H88CoN14O14P |
| 中文名 | 维生素B12
| | 英文名 | Vitamin B12
| | 别名 | 氰钴胺
氰钻胺素
维生素B12
维生素 B12
钴胺素,氰钴胺
维生素B12原料药
维生素B12, 氰钴胺
Α-5,6-二甲基-苯并咪唑氰钴胺
| | 英文别名 | VB12
hemomin
hepagon
hepavis
macrabin
hepcovite
lldfactor
hepacon-b12
Vitamin B12
Cyanocobalamin
lactobacilluslactisdornerfactor
cyano-5,6-dimethylbenzimidazole-cobalamin
5,6-dimethyl-1-(3-o-phosphono-alpha-d-ribofuranosyl)-1h-benzimidazolmonoes
| | CAS | 68-19-9
| | EINECS | 200-680-0 | | 化学式 | C63H88CoN14O14P
| | 分子量 | 1355.37 | | InChI | InChI=1/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31?,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1/rC63H89CoN14O14P/c1-30-20-40-41(21-31(30)2)77(29-73-40)58-53(87)54(42(27-79)90-58)92-93(88,89)91-32(3)26-72-50(86)18-19-60(8)38(22-47(69)83)57-63(11)62(10,25-49(71)85)37(14-17-46(68)82)52(78(63)64-28-65)34(5)56-61(9,24-48(70)84)35(12-15-44(66)80)39(74-56)23-43-59(6,7)36(13-16-45(67)81)51(75-43)33(4)55(60)76-57/h20-21,23,29,32,35-38,42,53-54,57-58,79,87H,12-19,22,24-27H2,1-11H3,(H2,66,80)(H2,67,81)(H2,68,82)(H2,69,83)(H2,70,84)(H2,71,85)(H,72,86)(H,88,89)/q+1/p-1/b39-23+,51-33-,52-34-/t32?,35-,36-,37-,38+,42-,53-,54-,57-,58+,60-,61+,62+,63+/m1/s1 | | InChIKey | RMRCNWBMXRMIRW-WZHZPDAFSA-L | | 熔点 | >300°C | | 沸点 | >300 °C | | 比旋光度 | 23656 -59 ± 9° (dil aq soln) | | 闪点 | 9℃ | | 水溶性 | Soluble | | 溶解度 | Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic. | | 酸度系数 | pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain) | | 存储条件 | 2-8°C | | 稳定性 | Hygroscopic. Keep cold and dry. | | 敏感性 | Hygroscopic | | 外观 | Crystalline Powder or Crystals | | 颜色 | Red to dark red | | Merck | 14,10014 | | BRN | 4122889 | | 暴露限值 | NIOSH: IDLH 25 mg/m3 | | 物化性质 | 深红色结晶或无定形结晶性粉末，无臭无味。熔点210～220℃(碳化变黑)。1g本品可溶于80mL水，溶于乙醇，不溶于丙酮、乙醚或氯仿。无水物易吸潮，结晶性氰钴胺在中性和微酸性溶液中对空气和热稳定性较好，在碱性、强酸及还原剂中不太稳定，不耐光和紫外线。 | | 产品用途 | 主要用于治疗巨幼红细胞贫血、营养性不良、失血性贫血、神经痛及障碍性疾患 | | MDL号 | MFCD00151092 | | 安全术语 | S24/25 - 避免与皮肤和眼睛接触。
| | 上游原料 | 氯化钴 氧化铅 放线菌 弱酸性丙烯酸系阳离子交换树脂 | | 下游产品 | 甲钴胺 | | 参考资料 展开查看 | 1. 韩龙, 阮国祥, 马杰希,等. 维生素B12生产菌的化学诱变和抗生素抗性筛选[J]. 精细与专用化学品, 2019, 27(01):40-43.
2. 陈银彬 王玉芳 侯志芳 等. Rg1联合B族维生素对急性心肌缺血小鼠NO释放及Rg1入脑量的影响[J]. 特产研究 2016(1):5-8.
3. Chen, Yin Bin, et al. "Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration." Journal of ginseng research 41.2 (2017): 209-214.https://doi.org/10.1016/j.jgr.2016.03.006
4. Li, Qingsi, et al. "Hemocompatible hemoadsorbent for effective removal of protein-bound toxin in serum." Journal of colloid and interface science 555 (2019): 145-156.https://doi.org/10.1016/j.jcis.2019.07.045
5. Xu, L., W. X. Cai, and B. J. Xu. "A systematic assesment on vitamins (B2, B12) and GABA profiles in fermented soy products marketed in China." Journal of Food Processing and Preservation 41.5 (2017): e13126.
6. Zheng, Peihe, et al. "Influence of B-complex vitamins on the pharmacokinetics of ginsenosides Rg1, Rb1, and Ro after oral administration." Journal of medicinal food 20.11 (2017): 1127-1132.https://doi.org/10.1089/jmf.2017.3922
7. [IF=6.06] Yin Bin Chen et al."Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration."J Ginseng Res. 2017 Apr;41:209
8. [IF=2.786] Peihe Zheng et al."Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration."J Med Food. 2017 Nov;20(11):1127-1132
9. [IF=2.19] L. Xu et al."A Systematic Assesment on Vitamins (B2, B12) and GABA Profiles in Fermented Soy Products Marketed in China."J Food Process Pres. 2017 Oct;41(5):e13126 |
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