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3681-99-0
时间：2023-07-15  来源：化工号   作者：C21H20O9
  • 葛根素
  • 葛根黄酮
  • 葛根素(分析标准品)
  • 黄豆甙元-8-葡萄糖甙
  • 4',7-二羟基-8-葡萄糖甙8-Β-D-葡萄吡喃糖-4',7-二羟基异黄酮8-beta-D-葡萄吡喃糖-4',7-二羟基异黄酮
    • 中文名 葛根素
    英文名 puerarin
    别名 葛根素
    葛根黄酮
    葛根素(分析标准品)
    黄豆甙元-8-葡萄糖甙
    4',7-二羟基-8-葡萄糖甙
    8-Β-D-葡萄吡喃糖-4',7-二羟基异黄酮
    8-beta-D-葡萄吡喃糖-4',7-二羟基异黄酮
    英文别名 puerarin
    Puerarine
    purerarin
    PSYCHOSINE
    Kudzu Extract
    PUERARIAROOT.P.E
    PUERARIN EXTRACT
    8-GLUCOSYLDAIDZEIN
    Kudzu Root extract
    8-glucosyldaidzein
    Pueraria root flavone
    DAIDZEIN-8-C-GLUCOSIDE
    Daidzein-8-C-glucoside
    7-hydroxy-3-(4-hydroxyphenyl)-
    7,4'-Dihydroxy-8-C-glucosylisoflavone
    4',7-Dihydroxy-8-C-Glucosylisoflavone
    7,4'-Dihydroxy-8-C-Glucosylisoflavone
    1-n-Dodecylazacycloneptan-2-one Nizatidine
    4H-1-Benzopyran-4-one,8-β-D-glucopyranosyl-
    1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]hexitol
    7-HYDROXY-3-[4-HYDROXYPHENYL]-1-BENZOPYRAN-4-ONE 8-[BETA-D-GLUCOPYRANOSIDE
    7-hydroxy-3-[4-hydroxyphenyl]-1-benzopyran-4-one 8-[beta-D-glucopyranoside
    8-beta-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    8-(Beta-D-Glucopyranosyl-7-Hydroxy-3-(4-Hydroxyphenyl)-4h-1-Benzopyran-4-One
    4H-1-Benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-
    (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
    (1xi)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
    7-Hydroxy-3-(4-Hydroxyphenyl)-8-[(2s,3s,4r,5r,6r)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Chromen-4-One
    CAS 3681-99-0
    EINECS 609-296-1
    化学式 C21H20O9
    分子量 416.38
    InChI InChI=1/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21?/m1/s1
    InChIKey HKEAFJYKMMKDOR-NCHCSYJDSA-N
    密度 1.614±0.06 g/cm3(Predicted)
    熔点 187-189°C
    沸点 688.0±55.0 °C(Predicted)
    闪点 245.1°C
    水溶性 Soluble in DMSO or DMF. Slightly soluble in water or ethanol
    蒸汽压 7.06E-20mmHg at 25°C
    溶解度 DMSO (Slightly), Methanol (Slightly)
    折射率 1.719
    酸度系数 6.46±0.20(Predicted)
    存储条件 2-8°C
    外观 Powder
    颜色 White to Off-white
    最大波长(λmax) ['303nm(MeOH)(lit.)']
    BRN 64198
    物化性质 白色针状结晶，加热可溶于水、甲醇、乙醇，不溶于乙酸乙酯、氯仿、苯，来源于葛根块根。
    产品用途 血管扩张药，用于治疗冠心病、各类心绞痛等病
    MDL号 MFCD00076007
    危险品标志 F - 易燃物品
    易燃物品
    C - 腐蚀性物品
    腐蚀性物品
    风险术语 R11 - 高度易燃。
    R34 - 引起灼伤。
    安全术语 S22 - 切勿吸入粉尘。
    S24/25 - 避免与皮肤和眼睛接触。
    S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
    S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。
    S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
    S16 - 远离火源。
    WGK Germany 3
    RTECS UO5216000
    FLUKA BRAND F CODES 10
    海关编号 29389090
    上游原料 69655-50-1
    参考资料 展开查看 1. 崔灵 张丽姝 陈萌萌 等. HPLC法同时测定知葛胶囊中葛根素、马钱苷、芒果苷以及芦丁的含量[J]. 沈阳药科大学学报 2018(7).
    2. 张丽娟 李燕 周剑丽 等. 一种降糖代餐粉的配方研究及质量评价[J]. 食品研究与开发 2019 40(09):105-110.
    3. 昶国平 魏雅蕾 林宏英 等. 丹葛保肝复方提取工艺的研究[J]. 中医药学报 2015(03):76-78.
    4. 黄仁术 孙峥峥 何惠利. 响应面法优化大别山野葛根多糖提取工艺研究[J]. 药物生物技术 2015 022(001):59-63.
    5. 卜雕雕 张丹 王昌利. 响应面法优化药对葛根-川芎提取工艺[J]. 辽宁中医药大学学报 2019 021(004):54-57.
    6. 王京龙, 郑丹丹, 王磊,等. 均匀设计法优化葛根半仿生提取工艺[J]. 中成药, 2017(5).
    7. 罗静, 陈诗晴, 李玉锋,等. 基于Box-Behnken设计优化复方葛根黄酮泡腾片的制备工艺研究[J]. 食品工业, 2018, v.39;No.262(07):175-180.
    8. 陈程,罗国平,冯锁民,张存劳,闫梦茹,郭艳茹.基于PB设计和BBD响应面法优化葛根-黄连药对提取工艺[J].中国药师,2018,21(02):228-231.
    9. 陆苑,黎娜,刘春花,潘洁,李勇军,王永林,孙佳.基于在体肠袢模型研究荭草活性成分在正常及心肌缺血模型大鼠的肠吸收特性[J].中国药理学通报,2020,36(08):1146-1151.
    10. 杨玉琴, 昶国平, 张志超,等. 复方丹参保肝颗粒入血成分研究[J]. 现代中药研究与实践, 2016, 030(003):37-40.
    11. 马晓云,刘洋,杨瑞瑞,罗志强,鲁利娜,赵海誉,赵慧辉.封闭肠环法用于葛根多成分肠壁吸收代谢研究[J].中国中药杂志,2017,42(08):1532-1538.
    12. 李博,赵安琦,张慧荣,李丽.应用超滤液相色谱和电喷雾质谱技术筛选MMP-2活性成分[J].分子科学学报,2015,31(02):94-100.
    13. 晏雨露, 徐驿, 赵继会,等. 微针辅助条件下葛根素微乳的经皮吸收研究[J]. 中草药, 2017, 048(001):95-101.
    14. 温海成, 杨颖欣, 叶信,等. 正交试验优选壮药三裂叶葛藤中葛根素的提取工艺研究[J]. 中国民族医药杂志, 2016(9).
    15. 陈松旺, 吴婷, 李煌,等. 畅脉乐胶囊的质量标准研究[J]. 福建医药杂志, 2020, 042(001):127-132.
    16. ]滕飞[1], 李博[1], 谢静[1],等. 葛根中抑制磷酸二酯酶4活性成分的筛选研究[J]. 分子科学学报(中,英文), 2018(1).
    17. 宋逍, 段玺, 徐萌,等. 葛根中有效成分葛根素膜分离工艺研究[J]. 时珍国医国药, 2019(10).
    18. 刘银莉, 王营. 葛根素对人胰腺癌PANC-1细胞增殖凋亡的影响[J]. 实用药物与临床, 2017(11):20-24.
    19. 陈媛, 黄晓松, 吴海金,等. 葛根素对大鼠脑缺血再灌注损伤后JAK2/STAT3信号通路的影响[J]. 湖南中医杂志, 2017, 04(v.33;No.218):149-152+170.
    20. 张晓丹, 杜伟, 张晨,等. 葛根素对缺氧性肺动脉高压及伴随的肺纤维化的作用[J]. 中国中药杂志, 2018, 43(12).
    21. 陈媛, 吴海金, 黄晓松,等. 葛根素对脑缺血再灌注大鼠海马组织P-STAT3、P53表达的影响[J]. 湖南中医药大学学报, 2018, 038(001):36-39.
    22. 王晶, 李洪敏, 艾芳,等. 葛根素的提取及对小鼠解酒护肝功能的鉴定[J]. 局解手术学杂志, 2015(04):358-361.
    23. 王帅, 李清清, 王帆,等. 葛根素药物纳米晶自稳定pickering乳的大鼠肠吸收特性研究[J]. 中国中药杂志, 2018, v.43(10):212-217.
    24. 胡亚丽,杨杰,庞茜茜.葛根素通过PTEN/PI3K/Akt通路调控人肝癌HepG2细胞增殖和凋亡的研究[J].现代消化及介入诊疗,2020,25(07):883-888.
    25. 桂卉,唐婷,严航,雷志钧.葛根黄酮类物质美白作用的研究[J].日用化学工业,2013,43(04):290-293+312.
    26. 严航, 杨晶, 唐婷,等. 葛根黄酮脂质体的制备及体外透皮实验研究[J]. 中成药, 2014, 36(003):623-625.
    27. 李玲, 谭力, 全沁果,等. 野葛块根异黄酮的提取及抗氧化研究[J]. 浙江农业学报, 2016, v.28;No.160(03):496-501.
    28. 李玲, 郭慧, 何福林,等. 野葛花葛根素的提取及稳定性研究[J]. 中国食品添加剂, 2017(3).
    29. 李玲, 全沁果, 沈艳欣, et al. 野葛藤地上部分葛根素的提取及稳定性研究[J]. 食品工业科技, 2016, 37(9):235-239.
    30. 黄仁术, 胡晓梦, 何惠利. 大别山野葛根异黄酮超声辅助提取工艺的响应面优化与还原力测定[J]. 中国药学杂志, 2015, 50(001):51-57.
    31. 吴文杰 邓阳 谭桂林 罗娟 陈秧 黄莺 张峰.一测多评法测定葛根药材中5种异黄酮类成分[J].中草药 2017 48(04):777-781.
    32. 潘洁, 杨淑婷, 孙佳, et al. 荭草中6种活性成分在正常和心肌缺血模型大鼠体内的肠吸收特征差异研究[J]. 中国药房, 2020(13).
    33. 牛晓静, 曹英杰, 段晓颖. 多指标正交试验优选通络调脂胶囊提取工艺[J]. 中药新药与临床药理, 2015, 026(006):851-854.
    34. 侯景龙, 毛跟年, 胡媛,等. 葛根,枳椇子解酒组合物体外抗氧化活性的研究[J]. 动物医学进展, 2020, 041(002):63-69.
    35. 任丽, 贾田芊, 李兴欢,等. 黄花油点草药材的质量标准研究[J]. 中国药房, 2019, 030(008):1083-1090.
    36. 杨梦玲, 尤朋涛, 何丽珊,等. 基于UPLC-MS/MS分析胃溃疡模型大鼠口服加味小柴胡颗粒后血浆中8种有效成分的药代动力学[J]. 中国中药杂志, 2018, 43(18).
    37. 陈丰,陈志清,钟桂玲,王贺,朱继金.葛根素预处理对心肌梗死模型大鼠HMGB1的表达及心肌细胞凋亡的影响[J].广西医科大学学报,2020,37(08):1404-1409.
    38. 范琳,王苗,马馨桐,沈颖昕,韩荣欣,张红印,严铭铭,邵帅.葛根抗氧化活性有效部位的筛选研究[J].食品研究与开发,2021,42(06):119-123.
    39. 王晶,赵重博,唐家琪,卜雕雕,邹俊波,张小飞,程江雪,王昌利.高效液相色谱法同时测定复方龙脉宁中7种成分的含量[J].中南药学,2020,18(11):1903-1905.
    40. 刘春花,王明金,杨淑婷,黎娜,陆苑,潘洁,李勇军,王永林,孙佳.基于外翻肠囊模型研究荭草提取物在正常和心肌缺血模型大鼠中的肠吸收特征[J].中国中药杂志,2021,46(01):196-205.
    41. 陈函,廉婷,杜远东,陈程,马宝.鼻用葛根素脂质体温敏凝胶剂的制备与质量评价[J].化工科技,2020,28(05):41-46.
    42. 鞠娜,张文风,翁丽丽.正交实验法优选玉液汤提取工艺[J].特产研究,2021,43(01):7-11.
    43. 李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038.
    44. Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu,A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin,Talanta,Volume 174
    45. Renshu, Huang, et al. "Extraction technology of isoflavone from Dabie Mountain's Pueraria lobata and determination of its reducing power." Pakistan journal of pharmaceutical sciences 27 (2014).
    46. Li, Na, et al. "Comparative Tissue Distribution of 6 Major Polyphenolic Compounds in Normal and Myocardial Ischemia Model Rats After Oral Administration of the Polygonum orientale L. Extract." Natural Product Communications 15.6 (2020): 1934578X20929447.ht
    47. Huang, W, Wen, Z, Wang, M, Xu, B, Zhou, B, Li, X. Anticomplement and antitussive activities of major compound extracted from Chimonanthus nitens Oliv. leaf. Biomedical Chromatography. 2020; 34:e4736. https://doi.org/10.1002/bmc.4736
    48. Zhang, Jifen, et al. "Development of an oral compound pickering emulsion composed of nanocrystals of poorly soluble ingredient and volatile oils from traditional chinese medicine." Pharmaceutics 10.4 (2018): 170.https://doi.org/10.3390/pharmaceutics1004017
    49. Yu, Yunru, et al. "Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases." Chinese medicine 16.1 (2021): 1-14.
    50. [IF=6.321] Jifen Zhang et al."Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine."Pharmaceutics. 2018 Dec;10(4):170
    51. [IF=6.057] Shasha Jing et al."A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin."Talanta. 2017 Nov;174:477
    52. [IF=5.396] Song Liu et al."The in silico and in vivo evaluation of puerarin against Alzheimer's disease."Food Funct. 2019 Feb;10(2):799-813
    53. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56
    54. [IF=3.645] Wenjie Wu et al."Simple, rapid, and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography."J Sep Sci. 2017 Jul;40(13):2827-2837
    55. [IF=3.361] Hongguang Zhang et al."Extraction of isoflavones from Puerariae lobata using subcritical water."Rsc Adv. 2018 Jun;8(40):22652-22658
    56. [IF=2.896] Bo Li et al."Preparative separation of isoflavones in plant extract of Pueraria lobata by high performance counter-current chromatography."Anal Methods-Uk. 2015 Feb;7(4):1321-1327
    57. [IF=2.19] Y.J. Chen et al."Phytochemical Profiles of Edible Kudzu (Pueraria thomsonii Benth) Grown in China as Affected by Thermal Processing."J Food Process Pres. 2017 Feb;41(1):e12754
    58. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518
    59. [IF=5.878] Hui-Xian Wang et al."Antiviral activity of puerarin as potent inhibitor of influenza virus neuraminidase."Phytother Res. 2021 Jan;35(1):324-336
    60. [IF=5.455] Yu Yunru et al."Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases."Chin Med-Uk. 2021 Dec;16(1):1-14
    61. [IF=4.872] Muhammad Waqas et al."Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions."Ecotox Environ Safe. 2020 Mar;190:110126
    62. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato
    63. [IF=4.759] Lu-lu Xu et al."Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry."J Chromatogr A. 2019 Nov;1606:460378
    64. [IF=4.171] Song Liu et al."In silico-determined compound from root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via p38MAPK-CREB signaling pathway."Food Funct. 2021 Feb;12(3):1039-1050
    65. [IF=3.943] Lumeng Niu et al."Puerarin inhibits Mycoplasma gallisepticum (MG-HS)-induced inflammation and apoptosis via suppressing the TLR6/MyD88/NF-κB signal pathway in chicken."Int Immunopharmacol. 2020 Nov;88:106993
    66. [IF=3.869] Huang Donghua et al."Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway."Stem Cells Int. 2020;2020:7126914
    67. [IF=3.512] Yan Cheng et al."Comparison of the Extraction Efficiency of Isoflavone Compounds from Puerariae lobatae by Ionic Liquids with 11 Anions and 8 Imidazolium-Based Cations."Acs Omega. 2020;5(15):8962–8971
    68. [IF=3.422] Wei Bin et al."Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis."J Microbiol. 2021 Oct;59(10):931-940
    69. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788
    70. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950
    71. [IF=2.984] Chenkai Wang et al."Comparative transcriptome analysis of roots, stems, and leaves of Pueraria lobata (Willd.) Ohwi: identification of genes involved in isoflavonoid biosynthesis."Peerj. 2021 Feb;9:e10885
    72. [IF=2.826] Kai Sheng et al."Simple voltammetric sensor detection for puerarin."Int J Environ An Ch. 2021;101(12):1635-1648
    73. [IF=2.574] Zeng Mao-Seng et al."Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice."Arch Virol. 2021 Sep;166(9):2387-2397
    74. [IF=2.082] Qin Guo et al."Synergistic inhibition effects of tea polyphenols as adjuvant of oxytetracycline on Vibrio parahaemolyticus and enhancement of Vibriosis resistance of Exopalaemon carinicauda."Aquac Res. 2021 Aug;52(8):3900-3910
    75. [IF=1.902] Yuan Lu et al."Comparative analysis of excretion of six major compounds of Polygonum orientale L. extract in urine, feces and bile under physiological and myocardial ischemia conditions in rats using UPLC–MS/MS."Biomed Chromatogr. 2021 Oct;35(10):e5174
    76. [IF=0.986] Na Li et al."Comparative Tissue Distribution of 6 Major Polyphenolic Compounds in Normal and Myocardial Ischemia Model Rats After Oral Administration of the Polygonum orientale L. Extract:."Nat Prod Commun. 2020;15(6):
    77. [IF=5.396] Jie Li et al."Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway."Food Funct. 2022 Jan;:
    78. [IF=5.682] Hengyue Zhu et al."The isoflavone puerarin exerts anti-tumor activity in pancreatic ductal adenocarcinoma by suppressing mTOR-mediated glucose metabolism."Aging-Us. 2021 Dec 15; 13(23): 25089–25105
    79. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245
    80. [IF=5.34] Lei Jin et al."Simultaneous optimization of the extraction process of Yangyin Yiqi Huoxue prescription with natural deep eutectic solvents for optimal extraction yield and antioxidant activity: A comparative study of two models."PHYTOMEDICINE. 2022 Jul;102
    81. [IF=2.552] Wang Sha et al."A newly isolated human intestinal strain deglycosylating flavonoid C-glycosides."ARCHIVES OF MICROBIOLOGY. 2022 Jun;204(6):1-8
    82. [IF=11.614] Pengfei He et al."Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase."Acta Pharmaceutica Sinica B. 2022 May;:
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