染料木黄酮 |
时间:2023-07-15 来源:化工号 作者:C15H10O5 |
中文名 | 染料木黄酮
| 英文名 | Genistein
| 别名 | 染料木素 染料木因 金雀异黄酮 染料木黄酮 木槿 芙蓉花 天然染料木素 金雀异黄酮,染料木黄酮 5,7,4-三羟基异黄酮 染料木黄酮(-20℃) 5,7,4 一三羟基异黄酮 染料木素GENISTEIN 4',5,7-三羟基异黄酮
| 英文别名 | prunetol Genistein C.I. 75610 sophoricol AKOS NCG1-0029 4,5,7-Trihydroxyisoflavone 4',5,7-TRIHYDROXYISOFLAVONE 4',5,7-trihydroxyisoflavone 4',5,7-trihydroxy-isoflavon 5,7,4'-TRIHYDROXYISOFLAVONE 5,7-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
| CAS | 446-72-0
| EINECS | 207-174-9 | 化学式 | C15H10O5
| 分子量 | 270.24 | InChI | InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H | InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N | 密度 | 1.2319 (rough estimate) | 熔点 | 297-298 °C | 沸点 | 333.35°C (rough estimate) | 闪点 | 217.1°C | 水溶性 | insoluble | 蒸汽压 | 6E-13mmHg at 25°C | 溶解度 | DMSO: soluble | 折射率 | 1.6000 (estimate) | 酸度系数 | 6.51±0.20(Predicted) | 存储条件 | -20°C | 稳定性 | Light Sensitive | 外观 | powder | 颜色 | off-white | Merck | 14,4391 | BRN | 263823 | 物化性质 | 白色固体。 | 产品用途 | 用于抗肿瘤、抗真菌、降血脂 | MDL号 | MFCD00016952 | 危险品标志 | Xi - 刺激性物品
Xn - 有害物品
| 风险术语 | R36/38 - 刺激眼睛和皮肤。
R22 - 吞食有害。
| 安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。
S24/25 - 避免与皮肤和眼睛接触。
S22 - 切勿吸入粉尘。
| WGK Germany | 3 | RTECS | NR2392000 | TSCA | Yes | 海关编号 | 29329990 | Hazard Class | IRRITANT | 上游原料 | 乙醚 | 下游产品 | 槐角苷 ALPINUMISOFLAVONE | 参考资料 展开查看 | 1. 朱春燕,王飞霞,李璐,安叶娟,来吉祥,张华峰,王凤忠.大豆芽中异黄酮的超声波-微波协同提取及其抑菌活性分析[J].中国油料作物学报,2017,39(02):245-252. 2. 徐成飞, 韦立群, 李通,等. 染料木素对HT29细胞IL-8分泌及Akt/NF-κB活化的影响[J]. 中国现代医学杂志, 2018, 28(30):17-21. 3. 张洪敏,曹世杰,何昕雅,邱峰,张德芹.染料木素对油酸诱导HepG2细胞脂质蓄积的影响[J].中国实验方剂学杂志,2019,25(18):71-75. 4. 李圆圆, 田晨颖, 刘晓美,等. 添加微量元素对黑豆发芽过程中成分的影响[J]. 食品工业科技, 2019, 40(09):104-110. 5. 申春莉, 沙见宇, 李曼,等. 灵芝固态发酵豆渣的抗氧化特性变化研究[J]. 食品研究与开发, 2019, 040(024):60-64. 6. 赵欣, 易若琨, 骞宇. 玻璃和不锈钢容器发酵水豆豉的乙醇提取物对结肠癌细胞的体外凋亡诱导效果比较[J]. 食品工业科技, 2017(10):303-308. 7. 崔方,韩增护,刘小花,杨亚飞,兰芝荟,封士兰.红芪提高免疫功能活性部位的谱效关系研究[J].中草药,2016,47(01):101-105. 8. 孙兰凤, 孙倩, 穆春旭,等. 蜂蜜中7种成分含量HPLC切换波长法测定[J]. 中国公共卫生, 2013(04):142-143. 9. 史艳艳, 刘庆生, 范志影,等. 雌激素质谱筛查分析方法的研究[J]. 饲料工业, 2015, 36(24):49-54. 10. 王飞霞 杨晓华 张华峰 朱春燕 李璐 王凤忠.3种豆芽中异黄酮、多酚的体外抗氧化活性及其对果蝇SOD、GSH-Px活力的影响[J].中国食品学报 2018 18(11):57-64. 11. 刘露 马金同 沈小梅 等. 一种保健酒中5种大豆异黄酮及芝麻素的超高效液相色谱检测法[J]. 酿酒 2019 046(004):86-88. 12. 朱怡霖, 张海生, 赵鑫帅,等. 大孔树脂分离纯化横山老黑豆酚类物质[J]. 食品与生物技术学报, 2019, 038(009):103-110. 13. 闫征 王帆 吴寒 等. 不同烫漂方式对碱蓬活性成分及抗氧化能力的影响[J]. 江苏农业学报 2017(5). 14. 靳羽慧, 刘长忠, 徐响,等. 蒸汽爆破对豆渣中大豆异黄酮的影响研究[J]. 中国粮油学报, 2017(10). 15. 唐君, 付强, 崔勐,等. 黄酮与溶菌酶相互作用的强度衰减-基质辅助激光解吸离子化-质谱研究[J]. 分析化学, 2016, 044(007):1071-1076. 16. 周凯文, 陈晓默, 刘慧琳,等. 多酚黄酮物质对晚期糖基化终产物的抑制研究[J]. 食品研究与开发, 2018, v.39;No.329(04):7-13. 17. 郭天赐, 赵石磊, 刘石生. 苦杏仁β-葡萄糖苷酶水解豆浆中大豆异黄酮的工艺研究[J]. 食品研究与开发, 2019(12). 18. 赵石磊, 何旭, 王爱珠,等. 酶法提高豆浆中大豆异黄酮苷元含量的工艺研究[J]. 食品工业, 2019, 040(001):100-104. 19. 黎映琼,蔡庆群,苏志强,陈标妹.不同产地木豆叶中5种黄酮类成分含量的比较及聚类分析[J].安徽农业科学,2020,48(20):203-205+209. 20. 王艳玲. 染料木素抑制MCR-1活性的作用机制的初步研究[D].吉林大学,2020. 21. 黄玉军,周帆,李颖华,于俊娟,顾瑞霞.植物乳杆菌58发酵豆乳产大豆异黄酮苷元条件的优化[J].现代食品科技,2021,37(02):183-190. 22. 李丹丹,梁宗锁,普布卓玛,杨宗岐,韩蕊莲,徐学选.干旱胁迫对紫花苜蓿黄酮类化合物含量及其合成途径关键酶活性的影响[J].西北植物学报,2020,40(08):1380-1388. 23. 周文红,郭咪咪,毕艳红,王朝宇,段章群.酶解制备苷元型大豆异黄酮[J].中国油脂,2020,45(12):100-104. 24. 常冠华,薄颖异,崔洁,徐露露,赵梓邯,王文全,侯俊玲.基于UPLC-Q-Exactive Orbitrap-MS分析甘草地上部分主要化学成分[J].中国中药杂志,2021,46(06):1449-1459. 25. 黄玉军,周帆,于俊娟,李颖华,顾瑞霞.高转化大豆异黄酮乳酸菌的筛选及在豆乳中的发酵特性[J].食品研究与开发,2021,42(03):157-162. 26. 曹冬英,李鸷,许文,隋利强,徐伟.4种市售黑豆及成品淡豆豉中异黄酮含量分析[J].药学研究,2020,39(10):581-584. 27. Huang, Guocheng, Weixi Cai, and Baojun Xu. "Improvement in beta-carotene, vitamin B2, GABA, free amino acids and isoflavones in yellow and black soybeans upon germination." LWT 75 (2017): 488-496.https://doi.org/10.1016/j.lwt.2016.09.029 28. Huang, Xiya, Weixi Cai, and Baojun Xu. "Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time." Food chemistry 143 (2014): 268-276.https://doi.org/10.1016/j.foo 29. Zhu, Yi-Lin, et al. "Composition, distribution, and antioxidant activity of phenolic compounds in 18 soybean cultivars." Journal of AOAC International 101.2 (2018): 520-528.https://doi.org/10.5740/jaoacint.17-0156 30. Liu, Mengyue, et al. "A high throughput screening method for endocrine disrupting chemicals in tap water and milk samples based on estrogen receptor α and gold nanoparticles." Analytical Methods 12.2 (2020): 200-204.DOI https://doi.org/10.1039/C9AY02179E 31. [IF=7.514] Xiya Huang et al."Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time."Food Chem. 2014 Jan;143:268 32. [IF=7.514] Lu Xu et al."A systematic, comparative study on the beneficial health components and antioxidant activities of commercially fermented soy products marketed in China."Food Chem. 2015 May;174:202 33. [IF=7.46] Yiming Liang et al."Molecularly imprinted electrochemical sensor for daidzein recognition and detection based on poly(sodium 4-styrenesulfonate) functionalized graphene."Sensor Actuat B-Chem. 2017 Nov;251:542 34. [IF=4.952] Guocheng Huang et al."Improvement in beta-carotene, vitamin B2, GABA, free amino acids and isoflavones in yellow and black soybeans upon germination."Lwt Food Sci Technol. 2017 Jan;75:488 35. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 36. [IF=3.645] Wenjie Wu et al."Simple, rapid, and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography."J Sep Sci. 2017 Jul;40(13):2827-2837 37. [IF=2.19] Y.J. Chen et al."Phytochemical Profiles of Edible Kudzu (Pueraria thomsonii Benth) Grown in China as Affected by Thermal Processing."J Food Process Pres. 2017 Feb;41(1):e12754 38. [IF=1.913] Zhu Yi-Lin et al."Composition, Distribution, and Antioxidant Activity of Phenolic Compounds in 18 Soybean Cultivars."J Aoac Int. 2018 Mar;101(2):520-528 39. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051 40. [IF=7.514] Xiaoming Yu et al."Impact of processing technologies on isoflavones, phenolic acids, and antioxidant capacities of soymilk prepared from 15 soybean varieties."Food Chem. 2021 May;345:128612 41. [IF=4.769] Jing Han et al."Qualitative and quantitative evaluation of Flos Puerariae by using chemical fingerprint in combination with chemometrics method."J Pharm Anal. 2021 Sep;: 42. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 43. [IF=4.411] Liqing Yin et al."Neuroprotective Potency of Tofu Bio-Processed Using Actinomucor elegans against Hypoxic Injury Induced by Cobalt Chloride in PC12 Cells."Molecules. 2021 Jan;26(10):2983 44. [IF=4.411] Liyu Luo et al."Integrated Phytochemical Analysis Based on UPLC-MS and Network Pharmacology Approaches to Explore the Quality Control Markers for the Quality Assessment of Trifolium pratense L.."Molecules. 2020 Jan;25(17):3787 45. [IF=4.171] Jinhong Xu et al."Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway."Food Funct. 2021 May;12(10):4556-4569 46. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328 47. [IF=3.645] Hongmin Zhang et al."Simultaneous determination of five isoflavones in rat plasma by LC-MS/MS: Comparative pharmacokinetic characteristics of Puerariae lobatae radix in normal and type 2 diabetic rats."J Sep Sci. 2019 Aug;42(16):2592-2601 48. [IF=3.512] Li-Li Hong et al."Altering the Regioselectivity of Cytochrome P450 BM3 Variant M13 toward Genistein through Protein Engineering and Variation of Reaction Conditions."Acs Omega. 2020;5(49):32059–32066 49. [IF=3.373] Wanning Chen et al."The composition differences between small black beans and big black beans from different habitats and its effects on the processing of Polygonum multiflorum."Phytochem Analysis. 2021 Sep;32(5):767-779 50. [IF=3] Run-Jia XU et al."3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels."Chin J Nat Medicines. 2019 Jun;17:413 51. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 52. [IF=2.984] Chenkai Wang et al."Comparative transcriptome analysis of roots, stems, and leaves of Pueraria lobata (Willd.) Ohwi: identification of genes involved in isoflavonoid biosynthesis."Peerj. 2021 Feb;9:e10885 53. [IF=1.797] Bihui Liu et al."Effects of Lactobacillus plantarum CQPC01‐fermented soybean milk on activated carbon‐induced constipation through its antioxidant activity in mice."Food Sci Nutr. 2019 Jun;7(6):2068-2082 54. [IF=7.514] Chengwen Lu et al."Effect of pulsed electric field on soybean isoflavone glycosides hydrolysis by β-glucosidase: Investigation on enzyme characteristics and assisted reaction."Food Chem. 2022 Jun;378:132032 55. [IF=8.128] Lijuan Yang et al."Sulfuric-acid-mediated synthesis strategy for multi-colour aggregation-induced emission fluorescent carbon dots: Application in anti-counterfeiting, information encryption, and rapid cytoplasmic imaging."J Colloid Interf Sci. 2022 Apr;6 56. [IF=4.57] Liu Jinyue et al."Identification and characterization of unique 5-hydroxyisoflavonoid biosynthetic key enzyme genes in Lupinus albus."Plant Cell Reports. 2021 Dec 01 57. [IF=6.953] Hongdong Song et al."Fabrication of chitosan-coated epigallocatechin-3-gallate (EGCG)-hordein nanoparticles and their transcellular permeability in Caco-2/HT29 cocultures."Int J Biol Macromol. 2021 Dec;: 58. [IF=7.514] Xuefeng Chen et al."Quantitative analyses for several nutrients and volatile components during fermentation of soybean by Bacillus subtilis natto."Food Chem. 2021 Dec;:131725 59. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245 60. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 61. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 62. [IF=7.514] Rui Wang et al."Functionalization of soy residue (okara) by enzymatic hydrolysis and LAB fermentation for B2 bio-enrichment and improved in vitro digestion."Food Chem. 2022 Sep;387:132947 |
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