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484-12-8
时间：2023-07-15  来源：化工号   作者：C15H16O3
  • 蛇床子素
  • 蛇床籽素
  • 蛇床子素(分析标准品)
  • OSTHOLE 蛇床子素
  • 蛇床子素, 来源于蛇床子
  • 7-甲氧基-8-异戊烯基香豆素
  • 蛇床子素(7-甲氧基-8-异戊烯基香豆素)
  • 7-甲氧基-8-异戊烯基香豆素,喔斯脑,欧芹酚甲醚
    • 中文名 蛇床籽素
    英文名 Osthole
    别名 蛇床子素
    蛇床籽素
    蛇床子素(分析标准品)
    OSTHOLE 蛇床子素
    蛇床子素, 来源于蛇床子
    7-甲氧基-8-异戊烯基香豆素
    蛇床子素(7-甲氧基-8-异戊烯基香豆素)
    7-甲氧基-8-异戊烯基香豆素,喔斯脑,欧芹酚甲醚
    英文别名 OSTHOL
    osthol
    Osthole
    OSTHOLE
    AKOS 236-34
    Chuanxiongzine
    Cnidium lactone(OSTHOLE )
    Common Cnidium Fruit Extract
    7-Methoxy-8-isopentenylcoumarin
    7-methoxy-8-(3-methyl-2-butenyl)-coumari
    7-Methoxy-8-(3-methyl-2-butenyl)-coumarin
    7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
    7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one
    CAS 484-12-8
    EINECS 1532714-185-1
    化学式 C15H16O3
    分子量 244.29
    InChI InChI=1/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
    InChIKey MBRLOUHOWLUMFF-UHFFFAOYSA-N
    密度 1.1263 (rough estimate)
    熔点 83-84°C
    沸点 347.2°C (rough estimate)
    闪点 167.6°C
    水溶性 12mg/L(25 ºC)
    蒸汽压 1.67E-06mmHg at 25°C
    溶解度 methanol: soluble10mg/mL, clear, colorless
    折射率 1.5570 (estimate)
    存储条件 Sealed in dry,2-8°C
    外观 powder
    颜色 white
    最大波长(λmax) ['322nm(MeOH)(lit.)']
    Merck 14,6895
    物化性质 溶于碱溶液、甲醇、乙醇、氯仿、丙酮、醋酸乙酯和沸石油醚等，不溶于水和石油醚。 来源于伞形科植物蛇床Cnidium monnieric(L.)Cuss．的果实
    MDL号 MFCD00076049
    WGK Germany 3
    RTECS GN7700000
    海关编号 29322090
    上游原料 3-氯-3-甲基-1-丁烯 三苯基膦 7-羟基香豆素
    下游产品 DIHYDROSESELIN
    参考资料 展开查看 1. 李文超, 2], 顾有方,等. 蛇床子素体外对蓝氏贾第鞭毛虫超微结构的影响[J]. 中国寄生虫学与寄生虫病杂志, 2014, 32(3):19-242.
    2. 刘畅, 吴娜, 田甜,等. 蛇床子素体外抗犬源蓝氏贾第鞭毛虫作用研究[J]. 中国病原生物学杂志, 2013, 008(011):1014-1016.
    3. 王青, 张云, 毛红娇, et al. 蛇床子素对TCP颗粒诱导小鼠颅骨溶解的影响[J]. 中国病理生理杂志, 2015, 31(12):2265-2270.
    4. 杨宁辉, 付金芳, 曹伶俐. 蛇床子素渗透泵控释片制备工艺的优化及其体外释药行为[J]. 中成药, 2018, 040(009):1954-1958.
    5. 高学成 仝燕. 冬青油促进蛇床子素和桅子苷透皮吸收的研究[J]. 中国中药杂志 2017 042(007):1338-1343.
    6. 王雪莲, 李敏敏, 胡军华,等. 18种香豆素类化合物对柑桔炭疽菌的抑制作用[J]. 中国南方果树, 2013, 42(004):73-74.
    7. 张珊.蛇床子素对慢性不可预见性应激抑郁模型大鼠对炎症因子及行为学的影响[J].中医临床研究,2020,12(25):25-28.
    8. 庞雯辉,赵希娟,陈西,张耀海,王成秋,赵其阳,焦必宁.超高效液相色谱-四极杆-飞行时间高分辨质谱法快速筛查柠檬果实中的生物活性成分[J].食品与发酵工业,2021,47(04):222-230+235-237.
    9. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214
    10. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214
    11. Waqas M, Wang Y, Li A, Qamar H, Yao W, Tong X, Zhang J, Iqbal M, Mehmood K, Li J. Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens. Antioxidants. 2019; 8(9):330. https://do
    12. Jing Liang, Jianlong Zhou, Youqin Xu, Xiaofei Huang, Xuefei Wang, Wenhua Huang, Hui Li, Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis, European Journal of Pharmacology, Volume 87
    13. Chen, Xi, et al. "Antipruritic effect of ethyl acetate extract from fructus cnidii in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis." Evidence-Based Complementary and Alternative Medicine 2020 (2020).https://doi.org/10.1155/2020/6981386
    14. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or
    15. [IF=7.514] Gui-Jie Li et al."Determination of citrus juice coumarins, furanocoumarins and methoxylated flavones using solid phase extraction and HPLC with photodiode array and fluorescence detection."Food Chem. 2019 Jan;271:29
    16. [IF=4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum."Molecules. 2016 Apr;21(4):468
    17. [IF=3.246] Sun Chaojie et al."Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole."Aaps Pharmscitech. 2018 Jul;19(5):2301-2310
    18. [IF=5.753] Liu Man et al."Constructing a Core Collection of the Medicinal Plant Angelica biserrata Using Genetic and Metabolic Data."Front Plant Sci. 2020 Dec;0:2099
    19. [IF=4.831] Ruili Li et al."Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway."Aging-Us. 2020 May 15; 12(9): 7945–7962
    20. [IF=4.52] Muhammad Waqas et al."Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens."Antioxidants-Basel. 2019 Sep;8(9):330
    21. [IF=4.162] Guijie Li et al."Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil."Drug Des Dev Ther. 2021; 15: 937–947
    22. [IF=3.263] Jing Liang et al."Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis."Eur J Pharmacol. 2020 May;874:172990
    23. [IF=2.629] Yang Niuniu et al."Desensitization of TRPV1 Involved in the Antipruritic Effect of Osthole on Histamine-Induced Scratching Behavior in Mice."Evid-Based Compl Alt. 2021;2021:4012812
    24. [IF=1.813] Chen Xi et al."Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis."Evid-Based Compl Alt. 2020;2020:6981386
    25. [IF=1.663] Wei Huang et al."Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo."Biopharm Drug Dispos. 2020 Feb;41(1-2):64-71
    26. [IF=4.566] Li Ruili et al."Integrated 16S rRNA Gene Sequencing and Metabolomics Analysis to Investigate the Important Role of Osthole on Gut Microbiota and Serum Metabolites in Neuropathic Pain Mice."Front Physiol. 2022 Feb;0:35
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