2058-46-0 |
| 时间：2023-07-15 来源：化工号 作者：C22H25ClN2O9 |
酸土霉素盐酸土霉素土霉素盐酸盐酸氧四环素盐酸土霉素(标准品)OXYTETRACYCLINE HCL 盐酸土霉素OXYTERACYCLINE HCL 土霉素盐酸盐(4S,4aR,5S,5aR,6S,12aS)-4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-2-并四苯甲酰胺盐酸盐
| 中文名 | 盐酸土霉素
| | 英文名 | Oxytetracycline HCL
| | 别名 | 酸土霉素
盐酸土霉素
土霉素盐酸
盐酸氧四环素
盐酸土霉素(标准品)
OXYTETRACYCLINE HCL 盐酸土霉素
OXYTERACYCLINE HCL 土霉素盐酸盐
(4S,4aR,5S,5aR,6S,12aS)-4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-2-并四苯甲酰胺盐酸盐
| | 英文别名 | nsc9169
OTC HCL
mepatar
GEOMYCIN
hydrocyclin
AQUACYCLINE
Oxytetracycline HCL
Oxytertracycline HCL
liquamycininjectable
Oxytetracycline HCL
oxytetracycline hydrochloride
5-hydroxytetracycline hydrochloride
10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-monohydrochloride
(3E,11S)-3-[amino(hydroxy)methylidene]-4a,6,7,11,12-pentahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
(2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
(4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha))-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
| | CAS | 2058-46-0
| | EINECS | 218-161-2 | | 化学式 | C22H25ClN2O9
| | 分子量 | 496.89 | | InChI | InChI=1/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1 | | 熔点 | 180°C | | 沸点 | 845.6°C at 760 mmHg | | 比旋光度 | -188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis) | | 闪点 | 465.2°C | | 水溶性 | >100 g/L | | 蒸汽压 | 2.17E-30mmHg at 25°C | | 溶解度 | Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline. | | PH值 | 2.0～3.0 (10g/l, 25℃) | | 存储条件 | 0-6°C | | 稳定性 | Hygroscopic | | 敏感性 | Light Sensitive | | 外观 | crystalline | | 颜色 | yellow | | 最大波长(λmax) | ['360nm(H2O)(lit.)'] | | Merck | 14,6976 | | BRN | 3853107 | | 物化性质 | 熔点 180°C
水溶性 >100 g/L
| | 产品用途 | 属广谱抗菌素，其抗菌谱、抗菌原理与四环素基本相同 | | MDL号 | MFCD00135815 | | 体外研究 | Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes. | | 体内研究 | The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis , the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter. For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days. | | 危险品标志 | Xn - 有害物品
Xi - 刺激性物品
| | 风险术语 | 63 - 可能有对胎儿造成伤害的危险。
| | 安全术语 | S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
S53 - 避免接触，使用前须获得特别指示说明。
S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。
| | WGK Germany | 2 | | RTECS | QI8225000 | | FLUKA BRAND F CODES | 8-10-23 | | TSCA | Yes | | 海关编号 | 29413000 | | 上游原料 | 碳 甲醇 硫酸 土霉素碱 盐酸 | | 参考资料 展开查看 | 1. 马珍珍, 赵涛, 何金兴. 皮克林乳液聚合法制备四环素分子印迹-生物炭复合材料[C]// 中国食品科学技术学会第十五届年会论文摘要集. 2018.
2. 刘慧, 李竞时, 朱小梅,等. 模拟日光照射下土霉素的光降解研究[J]. 中国科技论文, 2015, 000(021):2477-2480.
3. He, Baoshan, et al. "Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples." Food chemistry 300 (2019): 125179.https://doi.org/10.1016/j.foodc
4. [IF=2.896] Bao-Shan He et al."Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification."Anal Methods-Uk. 2018 Feb;10(7):783
5. [IF=13.273] Panpan Wang et al."Photocatalytic degradation of tetracyclines in liquid digestate: Optimization, kinetics and correlation studies."Chem Eng J. 2021 Apr;410:128327
6. [IF=10.588] Qiaopeng Tian et al."Characterization of a robust cold-adapted and thermostable laccase from Pycnoporus sp. SYBC-L10 with a strong ability for the degradation of tetracycline and oxytetracycline by laccase-mediated oxidation."J Hazard Mater. 2020 Jan;382:
7. [IF=7.514] Baoshan He et al."Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples."Food Chem. 2019 Dec;300:125179
8. [IF=4.616] Mengru Ti et al."A ratiometric nanoprobe based on carboxylated graphitic carbon nitride nanosheets and Eu3+ for the detection of tetracyclines."Analyst. 2021 Feb;146(3):1065-1073
9. [IF=5.882] Zi-Jian Zheng et al."MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria."Virulence. 2022;13(1):77-88 |
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