薯蓣皂素 |
| 时间：2023-07-15 来源：化工号 作者：C27H42O3 |
| 中文名 | 薯蓣皂素
| | 英文名 | diosgenin
| | 别名 | 薯蓣皂
薯蓣皂素
地奥配质
薯蓣皂苷元
薯蓣皂甙元
黄姜提取物
薯芋皂甙元
薯蓣皂苷配基
薯蓣皂素 DIOSGENIN
(25R)-螺甾-5-烯-3β-醇
(3β,25R)-螺甾-5-烯-3-醇
薯蓣皂苷元,薯芋皂素,薯蓣皂苷配基,地奥配质,(25R)-螺甾-5-烯-3Β-醇
| | 英文别名 | Diosgemom
Nitogenin
diosgenin
DIOCTYLMALONATE
spirost-5-en-3-ol
5-22-Spirosten-3-ol
5-25D-Spirosten-3-ol
25d-Spirost-5-en-3b-ol
20F,22F-Spirosten-3-ol
(3beta,25R)-spirost-5-en-3-ol
22alpha-Spirost-5-en-3beta-ol
(20R,25R)-spirost-5-en-3-beta-ol
DIOSGENIN (3B-HYDROXY-5A-SPIROSCENE)
(3beta,8xi,9xi,14xi,16xi,17xi,25R)-spirost-5-en-3-ol
(8xi,9xi,10xi,13xi,14xi,16xi,17xi,25R)-spirost-5-en-3-ol
| | CAS | 512-04-9
| | EINECS | 208-134-3 | | 化学式 | C27H42O3
| | 分子量 | 414.63 | | InChI | InChI=1/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20?,21?,22?,23?,24?,25+,26+,27-/m1/s1 | | 密度 | 1.0483 (rough estimate) | | 熔点 | 205-208°C | | 沸点 | 473.46°C (rough estimate) | | 比旋光度 | D25 -129° (c = 1.4 in CHCl3) | | 闪点 | 272.6°C | | 水溶性 | Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol. | | 蒸汽压 | 2.59E-13mmHg at 25°C | | 溶解度 | chloroform: 20mg/mL, clear, slightly yellow | | 折射率 | 1.4700 (estimate) | | 酸度系数 | 15.02±0.70(Predicted) | | 存储条件 | 2-8°C | | 外观 | Solid | | 颜色 | White to Pale Yellow | | Merck | 14,3295 | | BRN | 94582 | | 物化性质 | 薯蓣皂素为片状或针状结晶。熔点204-207℃。易溶于汽油、乙醇，氯仿等有机溶剂，不溶于水。山药粘液中的薯蓣皂素，是一种重要的医药原料，被医药界称为药用黄金。 薯蓣皂素经过发酵除去糖基后转化为薯蓣苷元，其抗炎性、降低血清胆固醇、改善胃肠功能、分泌血清抗体IgG的能力可大大提高。 | | 产品用途 | 是合成甾体激素药物的前体，用于合成氢化可的松、强的松、炔诺酮、肤轻松、地塞米松等各类甾体药物 | | MDL号 | MFCD00016887 | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36/37 - 穿戴适当的防护服和手套。
S24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 2 | | RTECS | WH1450000 | | 海关编号 | 29329990 | | 上游原料 | 黄姜 | | 下游产品 | 醋酸妊娠双烯醇酮酯 16,17-环氧黄体酮 17α-羟基黄体酮 17Α-羟基-21-碘黄体酮 16Β-溴孕甾-4-烯-17Α-醇-3,20-二酮 11a-羟基-16,17a-环氧孕酮 17α-羟基孕甾-4-烯-3,11,20-三酮 16,17-环氧孕烯醇酮 16Α,17Α-环氧-11-酮基黄体酮 孕甾-4-烯-17α,21-二醇-3,20-二酮-21-醋酸酯 | | 参考资料 展开查看 | 1. 赵丽蓉 罗汉 相英龙 等. Box-Benhken响应面法优化微波提取黄精总皂苷的条件[J]. 中国现代中药 2018 20(008):1010-1015.
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