5508-58-7 |
| 时间：2023-07-15 来源：化工号 作者：C20H30O5 |
穿心莲穿心连内脂穿心连内酯穿心莲内酯穿心莲内酯(标准品)穿心莲内酯.穿心莲提取物ANDROGRAPHOLIDE 穿心莲内酯
| 中文名 | 穿心莲内酯
| | 英文名 | Andrographolide
| | 别名 | 穿心莲
穿心连内脂
穿心连内酯
穿心莲内酯
穿心莲内酯(标准品)
穿心莲内酯.穿心莲提取物
ANDROGRAPHOLIDE 穿心莲内酯
| | 英文别名 | NSC 383468
Andrographolid
Andrographolide
UNII-410105JHGR
5-alpha,6-alpha,8a-alpha))-t
andrographolide,14-deoxy 11,12-didehydro
ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide
2(3h)-furanone,3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-met
3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one
4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
(S)-3-[(E)-2-[[(1R,4aα)-Decahydro-6β-hydroxy-5β-hydroxymethyl-5,8aβ-dimethyl-2-methylenenaphthalen]-1β-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-1,2,3,4,4a,5,6,7,8,8a-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene- 1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5- alpha,6-alpha,8a-alpha))-2(3H)-furanone
2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-
| | CAS | 5508-58-7
| | EINECS | 226-852-5 | | 化学式 | C20H30O5
| | 分子量 | 350.45 | | InChI | InChI=1/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16?,17-,19+,20+/m1/s1 | | InChIKey | BOJKULTULYSRAS-QPSYGYIJSA-N | | 密度 | d421 1.2317 | | 熔点 | 229-232 °C (lit.) | | 沸点 | 557.3±50.0 °C(Predicted) | | 比旋光度 | -126 º (c=1.5,HAc) | | 闪点 | 195.5°C | | 蒸汽压 | 9.64E-15mmHg at 25°C | | 溶解度 | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml). | | 折射率 | 1.567 | | 酸度系数 | 12.36±0.20(Predicted) | | 存储条件 | 2-8°C | | 稳定性 | Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | 外观 | Off-white solid | | 颜色 | Off-white | | 最大波长(λmax) | ['223nm(MeOH)(lit.)'] | | Merck | 14,633 | | BRN | 42762 | | 物化性质 | 白色方形或长方形结晶。熔点224-230℃（分解）。溶于沸乙醇，略溶于甲醇或乙醇，极微溶于氯仿，不溶于水或乙醚。无臭，味极苦。 | | 产品用途 | 具有清热解毒、抗菌消炎的作用，用于上呼吸道感染、细菌性痢疾、抗艾滋病毒等疾病的治疗 | | MDL号 | MFCD07778082 | | 危险品标志 | Xn - 有害物品
| | 风险术语 | R20/21/22 - 吸入、皮肤接触及吞食有害。
R36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S22 - 切勿吸入粉尘。
S24/25 - 避免与皮肤和眼睛接触。
S36 - 穿戴适当的防护服。
S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
| | WGK Germany | 3 | | RTECS | LU3490750 | | 海关编号 | 29322980 | | 上游原料 | 乙醇 | | 参考资料 展开查看 | 1. 崔丹丹, 曾令杰, 黄嘉玲,等. 基于主成分聚类和PLS回归分析的穿心莲质量等级评价研究[J]. 中草药, 2019.
2. 魏东艳, 魏冬梅, 滕利. 穿心莲内酯对人宫颈癌SiHa细胞增殖、凋亡及细胞周期的影响[J]. 中国妇幼保健, 2019, 034(014):3341-3344.
3. 涂玉绮, 唐维平. 穿心莲内酯对人舌鳞癌Tca8113细胞增殖和凋亡的影响[J]. 重庆医学, 2014(14):67-69+72.
4. 魏东艳, 魏冬梅, 滕利. 穿心莲内酯对宫颈癌U14荷瘤小鼠抗肿瘤作用的影响[J]. 中成药, 2020, v.42(02):211-214.
5. 王静娴, 李文, 陈婷,等. 穿心莲内酯纳米混悬剂的制备及评价[J]. 南京中医药大学学报, 2017, 33(003):313-316.
6. 孟慧, 许勇. 穿心莲内酯自乳化软胶囊的制备和溶出度评价[J]. 药学实践杂志, 2010, 28(3):184-185.
7. 邵晓婷, 张瑜, 郭择邻,等. 载穿心莲二萜内酯有效部位的透明质酸-苯硼酸纳米粒的制备[J]. 中成药, 2019, 041(011):2553-2560.
8. 邵艳华, 王建刚, 赖小平,等. 穿心莲二萜内酯类成分的高效薄层色谱指纹图谱研究[J]. 中药材, 2014, 37(2):219-223.
9. 曾吴静, 许玲, 何秋伶,等. 穿心莲农艺性状及其与二萜内酯成分相关性研究[J]. 中国中药杂志, 2019(15).
10. 黄嘉玲,曾令杰,崔丹丹,陈远霞,张晓元,张浚凇.穿心莲等级与叶茎比、浸出物及内酯类成分之间的相关性[J].中成药,2020,42(10):2675-2679.
11. Liu, G., & Liu, G. (2018). Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells. Oncology Letters, 15, 5301-5305. https://doi.org/10.3892/ol.2018.7941
12. [IF=2.311] Guo Liu et al."Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells."Oncol Lett. 2018 Apr;15(4):5301-5305
13. [IF=0] Ying Liu et al."Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner."Cell Physiol Biochem. 2017;44(4):1396-1410
14. [IF=4.101] Yan Li et al."Protective effects of andrographolide against cerebral ischemia‑reperfusion injury in mice."Int J Mol Med. 2021 Oct;48(4):1-13
15. [IF=1.287] Xiaofei Li et al."Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells:."J Int Med Res. 2020;48(8):
16. [IF=2.441] Loureiro Damasceno et al.Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability.European Journal Of Drug Metabolism And Pharmacokinetics.2021 Nov 23
17. [IF=4.932] Ronglong Luo et al."Andrographolide attenuates Mycoplasma gallisepticum-induced inflammation and apoptosis by the JAK/PI3K/AKT signal pathway in the chicken lungs and primary alveolar type II epithelial cells."INTERNATIONAL IMMUNOPHARMACOLOGY. 2022 Aug;109
18. [IF=5.811] |
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