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淫羊藿苷
时间：2023-07-15  来源：化工号   作者：C33H40O15
  • 淫羊藿
  • 淫羊藿苷
  • 淫羊藿甙
  • 淫羊藿提取物
  • 淫羊藿甙(单甙)
  • 淫羊藿苷(淫羊藿甙)
  • 淫羊藿提取物淫羊藿甙
  • ICARIIN 淫羊藿苷
  • 淫羊藿苷, 来源于淫羊藿
    • 中文名 淫羊藿苷
    英文名 Icariin
    别名 淫羊藿
    淫羊藿苷
    淫羊藿甙
    淫羊藿提取物
    淫羊藿甙(单甙)
    淫羊藿苷(淫羊藿甙)
    淫羊藿提取物淫羊藿甙
    ICARIIN 淫羊藿苷
    淫羊藿苷, 来源于淫羊藿
    英文别名 ICARRIN
    Icariin
    Icariln
    ICARIINE
    Icariine
    Epimedium
    Ieariline
    Epimedium P.E
    Epimediun P.E.
    epimedium extract
    Epimedium extract
    Epimedium herb Ext
    Horny goat weed extract
    Horny goat weed extract
    Icariin, froM EpiMediuM davidii Franch
    3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
    3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
    2,6-anhydro-1-deoxy-7-O-[7-(beta-D-glucopyranosyloxy)-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl]-L-glycero-L-manno-heptitol
    CAS 489-32-7
    EINECS 610-440-0
    化学式 C33H40O15
    分子量 676.66
    InChI InChI=1/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
    InChIKey TZJALUIVHRYQQB-XLRXWWTNSA-N
    密度 1.55
    熔点 223-225 ºC
    沸点 948.5±65.0 °C(Predicted)
    比旋光度 D15 -87.09° (in pyridine)
    闪点 300.9°C
    蒸汽压 0mmHg at 25°C
    溶解度 DMSO: soluble50mg/mL, clear, colorless to dark yellow
    折射率 1.679
    酸度系数 5.90±0.40(Predicted)
    存储条件 2-8°C
    稳定性 Light Sensitive
    外观 Powder
    颜色 light yellow to yellow
    最大波长(λmax) ['350nm(MeOH)(lit.)']
    Merck 14,3617
    物化性质 溶于乙醇、乙酸乙酯，难溶于水，不溶于醚、苯、氯仿。 来源于小檗科植物淫羊藿Epimedium brevicornum Maxim.
    MDL号 MFCD00210516
    安全术语 24/25 - 避免与皮肤和眼睛接触。
    WGK Germany 3
    RTECS DJ2980500
    海关编号 29389090
    上游原料 去水淫羊藿黄素 四乙酸堪非醇酯
    参考资料 展开查看 1. 侯剑伟 丁越 张彤 等. HPLC-DAD法同时测定调更汤中3个活性成分[J]. 中成药 2014 36(7):1454-1457.
    2. 谢媛媛 彭灵 苏加坤 等. 中药淫羊藿薄层色谱鉴别方法的建立[J]. 中药与临床 2017(04):20-24.
    3. 查琳 赵岩 祝洪艳 等. 人参茎叶总皂苷脂质体与水溶液在大鼠体内的血药浓度及药代动力学参数对比分析[J]. 中国中药杂志 2017(10).
    4. 彭静, 马益华, 陈彦,等. 固定化β-葡萄糖苷酶和蜗牛酶生物转化淫羊藿苷效率的比较研究[J]. 药学学报, 2015(12期):1652-1659.
    5. 彭静, 马益华, 陈彦,等. 微乳化-凝胶法制备微球固定化蜗牛酶并生物转化淫羊藿苷研究[J]. 中草药, 2015, 46(22):3326-3332.
    6. 刘玉亮, 梁广胜, 魏强强,等. 淫羊藿总黄酮及淫羊藿素体外抗骨肉瘤的研究[J]. 中成药, 2013, 35(010):2072-2077.
    7. 林思文, 李雪芹, 刘素云,等. 淫羊藿素联合阿霉素对人骨肉瘤MG-63细胞抑制作用的体外研究[J]. 中国中西医结合杂志, 2016(36):0729-734.
    8. 徐永明, 徐宏光, 张晓玲,等. 淫羊藿素药物在终板软骨细胞退变中的保护作用研究[J]. 赤峰学院学报(自然版), 2016(16):54-57.
    9. 鞠静, 彭玲玲, 潘宇政,等. 淫羊藿苷及宝藿苷I对气管切开模型大鼠肺组织病理学及炎症因子的影响[J]. 中国实验动物学报, 2019, 27(3).
    10. 周勇,刘晶,陈刚.淫羊藿苷对D-半乳糖诱导的脑衰老模型小鼠p53/p21信号通路的影响[J].中华中医药学刊,2019,37(09):2159-2162+2316.
    11. 周勇, 刘晶, 陈刚. 淫羊藿苷对D-半乳糖诱导的脑衰老模型小鼠皮层线粒体自噬的影响[J]. 中华中医药杂志, 2019, v.34(12):156-160.
    12. 朱彤彤, 黄连弟, 李俊玮,等. 淫羊藿苷对去卵巢大鼠骨质疏松症的保护作用及其机制[J]. 吉林大学学报(医学版), 2016, 42(005):915-919.
    13. 郭艳霞. 淫羊藿苷对去卵巢大鼠骨质疏松症的保护机制研究[J]. 四川中医, 2017, 035(007):63-65.
    14. 邓淑蓉, 潘宇政, 彭玲玲,等. 淫羊藿苷对气管切开插管大鼠肺部肥大细胞活性及炎性反应的影响[J]. 中华中医药杂志, 2018, 033(004):1594-1597.
    15. 鞠静, 谭人千, 钟勇,等. 淫羊藿苷对气管切开模型大鼠早期β-防御素-2和T细胞亚群的影响[J]. 中南大学学报:医学版, 2020(1):1-7.
    16. 杨芬, 刘彦礼, 闫岩,等. 淫羊藿苷对经血源性子宫内膜干细胞成心肌样细胞分化的影响[J]. 中国细胞生物学学报, 2016(11):1373-1381.
    17. 何玉琼, 赵璐, 沈燚,等. 淫羊藿苷对铁超载模型小鼠骨代谢的影响[J]. 药学学报, 2018(7).
    18. 杨轶舜 张彤 丁越 等. 3种淫羊藿苷次生产物的制备及HPLC测定[J]. 中成药 2020 042(003):779-782.
    19. 洪雅丹 张凌风 潘娉娉 等. HPLC法同时测定淫羊藿-骨碎补药对中7种成分[J]. 中成药 2019 041(006):1316-1321.
    20. 李瑞云 刘聪燕 许婷 等. 交联纳米SiO_2固定化蜗牛酶的制备表征及转化淫羊藿苷研究[J]. 中草药 2019 v.50;No.655(20):57-63.
    21. 刘玉萍, 丁学芳, 黄萌萌,等. 淫羊藿苷在不同骨质疏松大鼠模型中肠道吸收代谢研究[J]. 中国中药杂志, 2016(13):2532-2537.
    22. 赵岩, 侯莹莹, 唐国胜,等. 炮制前后淫羊藿不同提取物对ACE、α-葡萄糖苷酶的抑制活性及对亚硝酸根的清除活性研究[J]. 药物分析杂志, 2015(8期):1329-1334.
    23. 程素盼 张敏敏 梁琰 等. HPLC-DAD-ESI-TOF/MS法分析安神补脑液中化学成分[J]. 中成药 2019 041(004):743-748.
    24. 郭双双 郑芳芳 可丛雪 等. 乳酸片球菌AS1.2696来源的α-L-鼠李糖苷酶酶学性质分析[J]. 食品科学 2019 040(004):160-169.
    25. 王艺璇 李海涛 刘顺 等. 参葵通脉颗粒的质量标准研究[J]. 中药新药与临床药理 2020年31卷8期 984-989页 ISTIC PKU CSCD CA 2020.
    26. 涂艳, 熊莉娜, 柳湘洁,等. 淫羊藿苷对成骨细胞成骨分化的影响及Wnt/-catenin信号系统的关系研究[J]. 中国中医急症, 2017, 26(003):448-450.
    27. 范兴, 杨成梓, 包侠萍,等. 芪骨胶囊HPLC指纹图谱研究[J]. 中草药, 2014, 045(009):1257-1261.
    28. 王莹 高霞 陈彦 等. 卡波姆对淫羊藿总黄酮酶解效果的影响[J]. 中国实验方剂学杂志 2014 20(009):1-5.
    29. 李婧,王英哲,刘玉翠,景志贤,闫莉,郭俊杰,姜大成,肖井雷.地理环境因子对朝鲜淫羊藿黄酮类成分空间分布影响的探测分析[J].中国中药杂志,2019,44(24):5368-5374.
    30. 杨成梓 范兴 包侠萍 等. HPLC同时测定芪骨胶囊中5种成分的含量[J]. 中国实验方剂学杂志 2015 021(016):60-63.
    31. 刘聪燕 高霞 陈彦 等. 仿生酶解肠溶胶囊提高淫羊藿总黄酮口服生物利用度的可行性研究[J]. 中国医药工业杂志 2016(9期):1158-1164.
    32. 张燕. 大孔吸附树脂分离纯化淫羊藿EF5黄酮[J]. 北方药学, 2015, 000(011):11-13.
    33. 刘聪燕, 高霞, 黄萌萌,等. 淫羊藿总黄酮仿生酶解肠溶胶囊的制备及评价[J]. 中草药, 2016(20).
    34. 刘聪燕, 高霞, 陈彦,等. 淫羊藿总黄酮在骨质疏松大鼠体内的药动学行为[J]. 中成药, 2017, 39(008):1595-1600.
    35. 高霞, 刘璇, 陈彦,等. 淫羊藿总黄酮的生物转化过程分析[J]. 中国中药杂志, 2013, 38(23):4079.
    36. 高霞, 陈彦, 王莹,等. 糊精湿法制粒对淫羊藿总黄酮酶解的影响[J]. 中成药, 2014, 36(007):1392-1397.
    37. 张初瑜 陈素红 吴素香. 一测多评法测定复方人参片中的8种苷类成分[J]. 中国现代应用药学 2018 35(05):90-96.
    38. 彭静, 马益华, 陈彦,等. 固定化蜗牛酶同时生物转化淫羊藿中4种黄酮苷[J]. 中成药, 2016, 38(9):1984-1990.
    39. 李琦,孙贵才.淫羊藿苷对骨髓间充质干细胞铁死亡及向心肌样细胞分化的影响[J].中国组织工程研究,2021,25(13):1988-1992.
    40. 范小龙,陈冉,吴婉琴,刘国姣,黄坤,江丰.液相色谱串联质谱法测定食品中淫羊藿苷等20种功能成分[J].食品与机械,2021,37(01):86-93+98.
    41. 何俊慧,韦洁,李冬梅,何飞,陆国寿,韦冬梅,李懿,赵成坚,韦桂宁,李力.基于TLR4/NF-κB通路探讨蛤蚧提取物对利血平诱导抑郁大鼠神经炎症的影响[J].中国实验方剂学杂志,2021,27(09):56-62.
    42. 武通,陈东宁,许占江.基于VEGF/VEGFR-2信号通路研究淫羊藿苷促进大鼠胫骨干骨折愈合的作用机制[J].浙江中医药大学学报,2021,45(03):282-288+293.
    43. 刘聪燕,李瑞云,马程遥,刘玉萍,瞿鼎,李晓琦,陈彦.壳聚糖交联介孔二氧化硅固定化β-葡萄糖苷酶生物转化淫羊藿苷研究[J].中草药,2021,52(03):685-691.
    44. 兰海,刘欣妍,余玲,莫诺兰,张燕,郭子右,吴清.大孔树脂纯化淫羊藿中朝藿定与淫羊藿苷工艺研究[J].中草药,2020,51(17):4473-4481.
    45. 黄楷迪,刘敬霞,牛阳,马学琴,张婷,卜凡淑,任慧,郭盛,钱大玮,段金廒.回药扎里奴思方UPLC指纹图谱结合多成分含量测定的质控方法研究[J].南京中医药大学学报,2021,37(01):77-82.
    46. Wang, Lu, et al. "Characterization of interaction property of multi‐components in Gardenia jasminoides with aldose reductase by microdialysis combined with liquid chromatography coupled to mass spectrometry." Rapid Communications in Mass Spectrometry 30 (2
    47. Wang, Lu, et al. "Characterization of interaction property of multi‐components in Gardenia jasminoides with aldose reductase by microdialysis combined with liquid chromatography coupled to mass spectrometry." Rapid Communications in Mass Spectrometry 30 (2
    48. Jia, Xiaohe, et al. "Design, preparation, surface recognition properties, and characteristics of icariin molecularly imprinted polymers." Cogent Chemistry 1.1 (2015): 1059597.
    49. Liu, Congyan, et al. "Icariin combined with snailase shows improved intestinal hydrolysis and absorption in osteoporosis rats." Biomedicine & Pharmacotherapy 94 (2017): 1048-1056.https://doi.org/10.1016/j.biopha.2017.07.163
    50. Yang, Lihong, et al. "Bioactive molecule Icariin inhibited proliferation while enhanced apoptosis and autophagy of rat airway smooth muscle cells in vitro." Cytotechnology 71.6 (2019): 1109-1120.https://doi.org/10.1007/s10616-019-00348-9
    51. Cheng, Tao, et al. "Comparative pharmacokinetics study of icariin and icariside II in rats." Molecules 20.12 (2015): 21274-21286.https://doi.org/10.3390/molecules201219763
    52. [IF=6.529] Congyan Liu et al."Icariin combined with snailase shows improved intestinal hydrolysis and absorption in osteoporosis rats."Biomed Pharmacother. 2017 Oct;94:1048
    53. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466
    54. [IF=4.545] Yan-dan Zhou et al."Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway."Biomed Pharmacother. 2019 Jan;109:2309
    55. [IF=4.411] Tao Cheng et al."Comparative Pharmacokinetics Study of Icariin and Icariside II in Rats."Molecules. 2015 Dec;20(12):21274-21286
    56. [IF=3.935] Tong Wang et al."Metabolic profiling of icariin in rat feces, urine, bile and plasma after oral administration using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry."J Pharmaceut Biomed. 2019 May;168:155
    57. [IF=2.419] Lu Wang et al."Characterization of interaction property of multi-components in Gardenia jasminoides with aldose reductase by microdialysis combined with liquid chromatography coupled to mass spectrometry."Rapid Communications In Mass Spectrometry. 2016 Au
    58. [IF=5.34] Liping Zhang et al."Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: Role of ICA in DCM."Phytomedicine. 2021 Oct;91:153607
    59. [IF=4.432] Luya Pu et al."Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes."Eur J Pharmacol. 2021 Dec;912:174585
    60. [IF=4.411] Zhenxian Qin et al."A Widely Metabolomic Analysis Revealed Metabolic Alterations of Epimedium Pubescens Leaves at Different Growth Stages."Molecules. 2020 Jan;25(1):137
    61. [IF=4.36] Kun Shi et al."Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway."J Ethnopharmacol. 2022 Feb;284:114766
    62. [IF=3.765] Shun Liu et al."Simultaneous determination of seven effective components in Shenkui Tongmai granules based on UHPLC-MS/MS."J Pharm Pharmacol. 2021 Apr;73(6):758-766
    63. [IF=3.757] Congyan Liu et al."Enhanced hydrolysis and antitumor efficacy of Epimedium flavonoids mediated by immobilized snailase on silica."Process Biochem. 2019 Nov;86:80
    64. [IF=3.645] Junfeng Li et al."An LC-MS/MS method for simultaneous quantification of 11 components of Xian-Xiong-Gu-Kang in the plasma of osteoarthritic rats and pharmacokinetic analysis."J Sep Sci. 2021 Sep;44(18):3386-3397
    65. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556
    66. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950
    67. [IF=2.984] Xiao-Hua Yang et al."Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster."Peerj. 2020 Jan;8:e8361
    68. [IF=2.447] Ling Sun et al."Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF‑κB and PI3K/AKT pathways."Exp Ther Med. 2021 Sep;22(3):1-7
    69. [IF=1.986] Yang Du et al."Investigation of labile protein-ligand interactions by native electrospray ionization mass spectrometry."Int J Mass Spectrom. 2021 Apr;462:116524
    70. [IF=1.902] Ting Zhang et al."The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats."Biomedical Chromatography. 2021 Oct 21
    71. [IF=1.672] Yang Lihong et al."Bioactive molecule Icariin inhibited proliferation while enhanced apoptosis and autophagy of rat airway smooth muscle cells in vitro."Cytotechnology. 2019 Dec;71(6):1109-1120
    72. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621
    73. [IF=5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology."PHYTOMEDICINE. 2022 Jul;102:154177
    74. [IF=6.53] Pan Sun et al."Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis."BIOMEDICINE & PHARMACOTHERAPY. 2022 Jun;150:112975
    75. [IF=2.63] Li Hangchao et al."Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway."Evidence-based Complementary and Alternative Medicine. 2022;2022:
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