56-75-7 |
| 时间：2023-07-15 来源：化工号 作者：C11H12Cl2N2O5 |
| 中文名 | 氯霉素
| | 英文名 | chloroamphenicol
| | 别名 | 氯霉素
氯霉素杂质
氯霉素(兽用)
氯霉素(药用级)
盐酸环丙沙星 杂质D
D-苏-1-对硝基苯基-2-二氯乙酰氨基-1,3-丙二醇
D(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇
D-苏式-(-)-N-[alpha-(羟基甲基)-beta-羟基-对硝基苯乙基]-2,2-二氯乙酰胺
| | 英文别名 | chloromycetin
chloramphenicol
chloroamphenicol
,[theta-(theta,theta)]-
2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid
2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid
2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)
2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide
d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide
2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide
Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-
Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
| | CAS | 56-75-7
| | EINECS | 200-287-4 | | 化学式 | C11H12Cl2N2O5
| | 分子量 | 323.13 | | InChI | InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1 | | InChIKey | WIIZWVCIJKGZOK-RKDXNWHRSA-N | | 密度 | 1.6682 (rough estimate) | | 熔点 | 148-150°C(lit.) | | 沸点 | 644.9±55.0 °C(Predicted) | | 比旋光度 | 19.5 º (c=6, EtOH) | | 闪点 | 14 °C | | 水溶性 | 2.5 g/L (25 º C) | | 蒸汽压 | 1.63E-17mmHg at 25°C | | 溶解度 | absolute ethanol: soluble5-20mg/mL (as a stock solution) | | 折射率 | 20 ° (C=5, EtOH) | | 酸度系数 | 11.03±0.46(Predicted) | | 存储条件 | Keep in dark place,Inert atmosphere,2-8°C | | 外观 | powder | | 颜色 | white | | Merck | 14,2077 | | BRN | 2225532 | | 物化性质 | 白色或微黄带绿色针状结晶。熔点150.5-151.5℃(149.7-150.7℃)。在高真空下可以升华。微溶于水（2.5mg/ml，25℃），略溶于丙二醇（150.8mg/ml），易溶于甲醇、乙醇、丁醇、乙酸乙酯、丙酮，不溶于乙醚、苯、石油醚，植物油。味极苦。 | | 产品用途 | 用于治疗由伤寒杆菌、痢疾杆菌、大肠杆菌、流感杆菌、布氏杆菌、肺炎球菌等引起的感染 | | MDL号 | MFCD00078159 | | 危险品标志 | T - 有毒物品
F - 易燃物品
| | 风险术语 | R45 - 可能致癌。
R11 - 高度易燃。
R39/23/24/25 -
R23/24/25 - 吸入、皮肤接触及吞食有毒。
| | 安全术语 | S53 - 避免接触，使用前须获得特别指示说明。
S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
S16 - 远离火源。
S36/37 - 穿戴适当的防护服和手套。
| | 危险品运输编号 | 2811 | | WGK Germany | 3 | | RTECS | AB6825000 | | FLUKA BRAND F CODES | 3-10 | | TSCA | Yes | | 海关编号 | 29414000 | | Hazard Class | 3 | | 上游原料 | 4-硝基苯乙酮 二氯醋酸甲酯 甲苯 甲醇 甲醛 硫酸 乌洛托品 溴素 氯苯 乙醇 异丙醇 | | 下游产品 | 氯霉素棕榈酸酯 | | 参考资料 展开查看 | 1. 王潆莘, 赵衍辉, 王雪,等. 复方氯霉素硼酸酊的含量测定及有关物质检查[J]. 沈阳药科大学学报, 2019(8).
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