斯伐他汀 |
| 时间：2023-07-15 来源：化工号 作者：C25H38O5 |
舒降脂塞瓦停辛伐他新伐他汀斯伐他丁斯伐他汀辛伐他丁辛伐他汀西伐斯汀辛伐司他汀辛伐他汀D6(1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-(1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-基]乙基]-1-萘酚 2,2-二甲基丁酸酯
| 中文名 | 斯伐他汀
| | 英文名 | Simvastatin
| | 别名 | 舒降脂
塞瓦停
辛伐他
新伐他汀
斯伐他丁
斯伐他汀
辛伐他丁
辛伐他汀
西伐斯汀
辛伐司他汀
辛伐他汀D6
(1S,2S,6S,8S,8AR)-1,2,6,7,8,8A-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-
(1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-六氢-3,7-二甲基-8-[2-[(2R,4R)-四氢-4-羟基-6-氧代-2H-吡喃-2-基]乙基]-1-萘酚 2,2-二甲基丁酸酯
| | 英文别名 | Lodaiès
Simvastatin
7-beta,8-beta(2s*,4s*),8a-beta))-alph
(1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
[8-[2-(4-Hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate
[(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoat
[(3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
2,2-Dimethylbutanoic acid (1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]naphthalen-1β-yl ester
Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro- 4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha,3-alpha,7- beta,8-beta(2S*,4S*),8a-beta))
| | CAS | 79902-63-9
| | EINECS | 616-751-8 | | 化学式 | C25H38O5
| | 分子量 | 418.57 | | InChI | InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21?,23?/m0/s1 | | 密度 | 1.11±0.1 g/cm3(Predicted) | | 熔点 | 127-132 °C (lit.) | | 沸点 | 564.9±50.0 °C(Predicted) | | 比旋光度 | D25 +292° (c = 0.5% in acetonitrile) | | 闪点 | 184.8°C | | 蒸汽压 | 4.12E-15mmHg at 25°C | | 溶解度 | DMSO: ≥20mg/mL | | 折射率 | 1.53 | | 酸度系数 | 13.49±0.40(Predicted) | | 存储条件 | 2-8°C | | 稳定性 | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | | 敏感性 | Sensitive to humidity and air | | 外观 | solid | | 颜色 | white | | Merck | 14,8539 | | 物化性质 | 白色结晶性粉末，无臭。易溶于乙醇、丙酮或乙腈，较难溶于乙醚，几不溶于水。熔点135～138℃。 | | 产品用途 | 具有降低胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇的作用 | | MDL号 | MFCD00072007 | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36 - 穿戴适当的防护服。
S24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 2 | | RTECS | EK7798000 | | 海关编号 | 29322090 | | 上游原料 | 碘甲烷 环己烷 正丁胺 苯硼酸 | | 参考资料 展开查看 | 1. 张月晓,李萍,李炳庆,陈健.辛伐他汀通过NF-κB p65通路影响食管癌细胞增殖[J].中国病理生理杂志,2020,36(09):1690-1695.
2. [IF=8.456] Hongfei Qi et al."Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair."Acs Appl Mater Inter. 2019;11(8):8625–8634
3. [IF=2.69] Xiaowei Yuan et al."Using co-axial electrospray deposition to eliminate burst release of simvastatin from microparticles and to enhance induced osteogenesis."J Biomat Sci-Polym E. 2019;30(5):355-375
4. [IF=11.161] Feng Jiao et al."Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis."J Exp Clin Canc Res. 2020 Dec;39(1):1-18
5. [IF=3.24] Bingli Zhao et al."Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice."Plos One. 2019 Jun;14(6):e0218543
6. [IF=2.1] Yuyan Zhang et al."Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression."Mol Med Rep. 2021 Jan;23(1):1-1
7. [IF=4.33] Le Gu et al."Study on chemical constituents of Folium Artemisiae argyi Carbonisatum, toxicity evaluation on zebrafish and intestinal hemostasis."Saudi Pharm J. 2022 Mar;:
8. [IF=4.24] Dan Zhang et al."Assessment of the anti-tumor activity of cyanidin-3-O-arabinoside from apple against APN, JAK, and EZH2 target proteins."Food Bioscience. 2022 May;:101788 |
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