阿奇霉素 |
| 时间：2023-07-15 来源：化工号 作者：C38H72N2O12 |
阿奇霉素阿奇毒素阿泽红霉素AZITHROMYCIN 阿奇霉素阿奇霉素 (AZITHROMYCIN)AZITHROMYCIN 阿奇霉素 标准品9-脱氧-9A-甲基-9A-氮杂-9A-红霉素A9-脱氧-9a-氮杂-9a-甲基-9a-红霉素 A
| 中文名 | 阿奇霉素
| | 英文名 | Azithromycin
| | 别名 | 阿奇霉素
阿奇毒素
阿泽红霉素
AZITHROMYCIN 阿奇霉素
阿奇霉素 (AZITHROMYCIN)
AZITHROMYCIN 阿奇霉素 标准品
9-脱氧-9A-甲基-9A-氮杂-9A-红霉素A
9-脱氧-9a-氮杂-9a-甲基-9a-红霉素 A
| | 英文别名 | Sumamed
Azitromvcin
Azithromycin
Azithromycine
9-deoxo-9a-methyl-9a-aza-homoerythromycin A
9-Deoxo-9-methyl-9a-aza-9-homoerythromycin A
N-METHYL-11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCIN A
N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A
9-DEOXO-9ALPHA-METHYL-9ALPHA-AZA-HOMOERYTHROMYCIN A
11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-tr
11-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-2-ETHYL-3,4,10-TRIHYDROXY-14-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-3,5,6,8,10,12,13-HEPTAMETHYL-1-OXA-6-AZA-CYCLOPENTADECAN-15-ONE
1-Oxa-6-azacyclopentadecan-15-one,13-((2,6-dideoxy-3-C-methyl-1-3-O-methyl-alpha-L-ribo-hexopyranosyl)-oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)
(2R,3S,4R,5S,6R,8R,11S,12R,13R,14S)-5-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-ethyl-6,12,13-trihydroxy-3-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-2,4,6,8,10,11,13-heptamethyl-15-oxa-10-azacyclopentadecan-1-one
| | CAS | 83905-01-5
| | EINECS | 617-500-5 | | 化学式 | C38H72N2O12
| | 分子量 | 748.98 | | InChI | InChI=1/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22-,23-,24+,25-,26+,27+,28-,29-,30+,31-,32+,33+,35+,36-,37-,38+/m1/s1 | | 密度 | 1.18±0.1 g/cm3(Predicted) | | 熔点 | 113-115°C | | 沸点 | 822.1±65.0 °C(Predicted) | | 比旋光度 | D20 -37° (c = 1 in CHCl3) | | 闪点 | 451°C | | 蒸汽压 | 2.51E-31mmHg at 25°C | | 溶解度 | Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride. | | 折射率 | 1.536 | | 酸度系数 | pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain) | | 存储条件 | Sealed in dry,2-8°C | | 稳定性 | Stable. Incompatible with strong oxidizing agents. | | 外观 | neat | | 颜色 | White to Off-White | | 物化性质 | 白色结晶。熔点113--115℃。[α] D20-37°(C=1，氯仿)。 | | 产品用途 | [用途] 用于呼吸道感染、尿路感染、皮肤及软组织感染和性传播疾病
| | MDL号 | MFCD00873574 | | 危险品标志 | Xi - 刺激性物品
Xn - 有害物品
| | 风险术语 | 42/43 - 吸入及皮肤接触可能致敏。
| | 安全术语 | S22 - 切勿吸入粉尘。
S36/37 - 穿戴适当的防护服和手套。
S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
| | WGK Germany | 2 | | RTECS | RN6960000 | | 海关编号 | 29419090 | | 参考资料 展开查看 | 1. 董靖,张露珊,刘绍春,张国栋,周顺,杨秋红,艾晓辉.1株克氏原螯虾肺炎克雷伯菌的分离鉴定及药物敏感性分析[J].华中农业大学学报,2021,40(01):93-98
2. 陈书鑫,王静,何士冲,刘铮铮,冯华军,穆朋倩.超高效液相色谱串联质谱法测定水体中17种抗生素[J].中国环境监测,2020,36(06):119-126.
3. Jiang, Fa-Xing, et al. "Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Hefei (2014–2015): genetic characteristics of antimicrobial resistance." BMC infectious diseases 17.1 (2017): 1-6.https://doi.org/10.1186/s12879-017-2472-z
4. Wang, Jinli, et al. "In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia." Poultry science 98.1 (2019): 373-380.https://doi.org/10.3382/ps/pey356
5. Chunxi Zhao, Yang Jiao, Zhe Gao, Yaling Yang, Hong Li, N, S co-doped carbon dots for temperature probe and the detection of tetracycline based on the inner filter effect, Journal of Photochemistry and Photobiology A: Chemistry, Volume 367, 2018, Pages 137-
6. [IF=3.09] Jiang Fa-Xing et al."Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Hefei (2014–2015): genetic characteristics of antimicrobial resistance."Bmc Infect Dis. 2017 Dec;17(1):1-6
7. [IF=6.057] Ruirui Xie et al."Lanthanide-functionalized metal-organic frameworks based ratiometric fluorescent sensor array for identification and determination of antibiotics."Talanta. 2021 Aug;231:122366
8. [IF=3.352] Jinli Wang et al."In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia."Poultry Sci. 2019 Jan;98:373
9. [IF=2.986] Cheng Hao et al."Electrospun Nanofibers with High Specific Surface Area to Prepare Modified Electrodes for Electrochemiluminescence Detection of Azithromycin."J Nanomater. 2021;2021:9961663 |
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