96829-58-2 |
| 时间：2023-07-15 来源：化工号 作者：C29H53NO5 |
| 中文名 | 奥尔利司他
| | 英文名 | Orlistat
| | 别名 | 赛尼可
奥列司他
奥利司他
奥尔利司他
四氢利泼斯汀
奥利司他(甾体)
奥利司他[发酵类]
奥利斯他(脂酶抑制剂)
奥利司他, 脂肪酶抑制剂
ORLISTAT奥利司他
| | 英文别名 | XENICAL
Orlistat
ORLISTAT
RO-18-0647
Orlipastat
Orlistat(synthesis)
Orlistat(FerMentation)
(-)-TETRAHYDROLIPSTATIN
(-)-Tetrahydrolipstatin(EquivalentToOrlistat)
(1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-D-leucinate
N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER
[(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl] (2S)-2-formamido-4-methyl-pentanoate
(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER
| | CAS | 96829-58-2
| | EINECS | 639-755-1 | | 化学式 | C29H53NO5
| | 分子量 | 495.73 | | InChI | InChI=1/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25?,26-,27-/m0/s1 | | InChIKey | AHLBNYSZXLDEJQ-FWEHEUNISA-N | | 密度 | 0.976±0.06 g/cm3(Predicted) | | 熔点 | <50 °C | | 沸点 | 615.9±30.0 °C(Predicted) | | 比旋光度 | D20 -32.0° (c = 1 in chloroform) | | 闪点 | 326.3°C | | 蒸汽压 | 4.23E-15mmHg at 25°C | | 溶解度 | DMSO: 19mg/mL | | 折射率 | 1.469 | | 酸度系数 | 14.59±0.23(Predicted) | | 存储条件 | 2-8°C | | 稳定性 | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. | | 外观 | solid | | 颜色 | white | | Merck | 14,6869 | | MDL号 | MFCD05662360 | | WGK Germany | 3 | | RTECS | OH3167600 | | 海关编号 | 29322090 | | 参考资料 展开查看 | 1. 李强, 徐天任, 吕畅,等. 山楂饮片对胰脂肪酶活性的抑制作用研究[J]. 药学研究, 2020, v.39(05):19-23.
2. 张丹, 姚正颖, 侯北伟,等. 霜桑叶提取物对胰脂肪酶活性抑制作用的研究[J]. 食品工业科技, 2017, 038(003):52-56.
3. 张丹,姚正颖,侯北伟,张卫明,孙力军.香水莲花提取物对胰脂肪酶活性的抑制作用[J].食品科技,2017,42(03):227-231.
4. 陈永丽,黄俊僮,王玲,姚开,贾冬英.桑叶多糖的化学组成及其对胰脂肪酶的抑制作用研究[J].食品科技,2021,46(03):162-166.
5. [IF=6.165] Sha Li et al."Mechanistic insights into the inhibition of pancreatic lipase by apigenin: Inhibitory interaction, conformational change and molecular docking studies."J Mol Liq. 2021 Aug;335:116505
6. [IF=5.396] Hang Xu et al."The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats."Food Funct. 2019 Oct;10(10):6517-6532
7. [IF=4.451] Sha Li et al."Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat."J Funct Foods. 2020 Sep;72:104041
8. [IF=3.167] Hao-Xiang Gao et al."Potential of phenolic compounds in Ligustrum robustum (Rxob.) Blume as antioxidant and lipase inhibitors: Multi-spectroscopic methods and molecular docking."J Food Sci. 2022 Feb;87(2):651-663 |
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