27113-22-0 |
| 时间：2023-07-15 来源：化工号 作者：C17H26O3 |
姜酮酚食品级姜酮酚5-去氧-6-姜辣醇姜酮酚5-去氧-6-姜辣醇
| 中文名 | 姜酮酚
| | 英文名 | 6-paradol
| | 别名 | 姜酮酚
食品级姜酮酚
5-去氧-6-姜辣醇
姜酮酚5-去氧-6-姜辣醇
| | 英文别名 | PARADOL
5-Paradol
6-paradol
1-(4-Hydroxy-3-methoxyphenyl)decan-3-one
1-(4-Hydroxy-3-methoxyphenyl)-3-decanone
1-(3-Methoxy-4-hydroxyphenyl)-3-decanone
1-(4-hydroxy-3-methoxyphenyl)decan-5-one
3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-
| | CAS | 27113-22-0
| | EINECS | 248-228-1 | | 化学式 | C17H26O3
| | 分子量 | 278.39 | | 密度 | 1.0690 g/cm3 | | 沸点 | 406.4±30.0 °C(Predicted) | | JECFA Number | 2021 | | 溶解度 | Chloroform (Slightly), Methanol (Slightly) | | 折射率 | 1.5232 (589.3 nm 20℃ | | 酸度系数 | 10.02±0.20(Predicted) | | 存储条件 | Sealed in dry,Room Temperature | | 外观 | Solid | | 颜色 | White to Brown | | 体外研究 | Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism. | | 体内研究 | Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study. | | 上游原料 | 香草醇 2-壬酮 4-苄氧基-3-甲氧基苯甲醛 香兰素 1-溴代庚烷 |
|
|
|
|
