379270-38-9 |
| 时间：2023-07-15 来源：化工号 作者：C25H33N6O9P |
| 中文名 | GS 7340 富马酸盐
| | 英文名 | GS-7340 Fumarate
| | 别名 | GS7340单盐
富马酸GS-7340
泰诺福韦艾拉酚胺半盐
GS 7340 富马酸盐
泰诺福韦艾拉酚胺富马酸盐
替诺福韦艾拉酚胺富马酸单盐
替诺福韦艾拉酚胺富马酸盐[单盐]
| | 英文别名 | vemlidy
GS-7340 Fumarate
GS-7340 (fuMarate)
Tenofovir alafenamide-19
tenofovir alafenamide fumarate (TAF)
| | CAS | 379270-38-9
| | EINECS | 223-388-5 | | 化学式 | C25H33N6O9P
| | 分子量 | 592.55 | | 溶解度 | DMSO: ≥ 36 mg/mL | | 存储条件 | under inert gas (nitrogen or Argon) at 2-8°C | | 体外研究 | Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. | | 体内研究 | Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF). |
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