盐酸艾替伏辛 |
| 时间：2023-07-15 来源：化工号 作者：C17H18Cl2N2O |
| 中文名 | 盐酸艾替伏辛
| | 英文名 | Etifoxine Hydrochloride
| | 别名 | 盐酸艾替伏辛
盐酸依替福辛
艾替伏辛盐酸盐
| | 英文别名 | StresaM
Etifoxine Hydrochloride
HOE-36801 hydrochloride
Etifoxine·hydrochloride
2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride
6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride
6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
| | CAS | 56776-32-0
| | EINECS | 260-380-0 | | 化学式 | C17H18Cl2N2O
| | 分子量 | 337.24362 | | 熔点 | ND | | 溶解度 | DMSO: ≥5mg/mL | | 存储条件 | -20°C | | 外观 | powder | | 颜色 | white to beige | | 体外研究 | Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX. | | 体内研究 | Etifoxine competitively inhibits [ 35 S]TBPS binding with micromolar potency in rat brain. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice. Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice. BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lowerplasma levels of the compound at 15 and 30 min. | | 危险品标志 | Xn - 有害物品
| | 风险术语 | 22 - 吞食有害。
| | WGK Germany | 3 |
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