海兔毒素 |
| 时间：2023-07-15 来源：化工号 作者：C42H68N6O6S |
| 中文名 | 海兔毒素
| | 英文名 | DOLASTATIN 10
| | 别名 | 海兔毒素
尾海兔素10
微管蛋白聚合抑制剂(DOLASTATIN 10)
(S)-2-((S)-2-(二甲基氨基)-3-甲基丁酰胺基)-N-((3R,4S,5S)-3-甲氧基-1-((S)-2-((1R,2R)-1-甲氧基-2-甲基-3-氧代-3-(((S)-2-苯基-1-(噻唑-2-基)乙基)氨基)丙基)吡咯烷-1-基)-5-甲基-1-氧代庚烷-4-基)-N,3-二甲基丁酰胺
| | 英文别名 | Dolastain10
B720389K560
DOLASTATIN 10
dolastatin 10
Dolastatin 10 (NSC-376128)
From dolabella auricularia (sea hare)
L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-
L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-
(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
| | CAS | 110417-88-4
| | 化学式 | C42H68N6O6S
| | 分子量 | 785.09 | | 密度 | 1.116±0.06 g/cm3(Predicted) | | 沸点 | 903.6±65.0 °C(Predicted) | | 酸度系数 | 13.81±0.46(Predicted) | | 存储条件 | -20°C | | 体外研究 | Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10 −5 -10 −6 μg/mL (10 −2 -10 −3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10. | | 危险品运输编号 | 3172 | | Hazard Class | 6.1(b) | | Packing Group | III | | 上游原料 | (3S,4S,5S) - 4 - ((((苄氧基)羰基)(甲基)氨基)-3-甲氧基-5-甲基庚酸叔丁 N-BOC-L-脯氨醛 N,N-二甲基-L-缬氨酸 BOC-L-异亮氨酸 |
|
|
|
|
