洛度沙胺氨丁三醇 |
| 时间：2023-07-15 来源：化工号 作者：C11H6ClN3O6.2C4H11NO3 |
洛度沙胺氨丁三醇2-氨基-2-(羟甲基)丙烷-1,3-二醇 半(2,2'-((2-氯-5-氰基-1,3-亚苯基)双(氮烷二基))双(2-氧代乙酸盐) )
| 中文名 | 洛度沙胺氨丁三醇
| | 英文名 | Lodoxamide tromethamine
| | 别名 | 洛度沙胺氨丁三醇
2-氨基-2-(羟甲基)丙烷-1,3-二醇 半(2,2'-((2-氯-5-氰基-1,3-亚苯基)双(氮烷二基))双(2-氧代乙酸盐) )
| | 英文别名 | AlMide
AloMide
U-42585-E
LodoxaMide troMetaMol
Lodoxamidetromethamine
Lodoxamide tromethamine
LodoxaMide troMethaMineon
LodoxaMide troMethaMine salt
Lodoxamide tromethamine (U 42585 E)
| | CAS | 63610-09-3
| | 化学式 | C11H6ClN3O6.2C4H11NO3
| | 分子量 | 553.906 | | 存储条件 | under inert gas (nitrogen or Argon) at 2–8 °C | | 体外研究 | lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45 Ca influx with associated histamine release in purified rat peritoneal mast cells. | | 体内研究 | Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep. |
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