托尔米汀钠 |
| 时间：2023-07-18 来源：化工号 作者：C15H14NO3.Na.2H2O |
| 中文名 | 托尔米汀钠
| | 英文名 | tolmetin sodium dihydrate
| | 别名 | 灭定钠
托尔米汀钠
托美丁钠(二水)
托美丁钠二水合物
托美丁钠 USP标准品
1-甲基-5-(P-甲苯酰基)吡咯-2-乙酸钠盐
2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水)
| | 英文别名 | TOLMELINSODIUM
Tolmetin Sodium
tolmetinsodiumdihydrate
sodiumtolmetindihydrate
tolmetin sodium dihydrate
Sodium tolmetin dihydrate
Tolmetinsodiumsaltdihydratecrystalline
1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate
5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate
1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate
1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
| | CAS | 64490-92-2
| | EINECS | 626-708-5 | | 化学式 | C15H14NO3.Na.2H2O
| | 分子量 | 315.3 | | InChI | InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1; | | InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M | | 熔点 | 155-157 (dec.) | | 沸点 | 483.2°C at 760 mmHg | | 闪点 | 246°C | | 水溶性 | Soluble in water | | 蒸汽压 | 3.79E-10mmHg at 25°C | | 溶解度 | Methanol (Slightly), Water (Slightly) | | 存储条件 | -20°C Freezer | | 外观 | Solid | | 颜色 | White to Beige | | 体外研究 | Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat. Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner. Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth. | | 体内研究 | Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg. Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity. | | 危险品标志 | Xn - 有害物品
| | 风险术语 | R22 - 吞食有害。
R38 - 刺激皮肤。
| | 安全术语 | 36 - 穿戴适当的防护服。
| | WGK Germany | 3 | | RTECS | UX9280000 | | 海关编号 | 2933995500 |
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