1392275-56-7 |
| 时间：2023-07-15 来源：化工号 作者：C25H33N6O9P |
| 中文名 | 替诺福韦艾拉酚胺富马酸盐
| | 英文名 | Tenofovir Alafenamide fumarate
| | 别名 | 替诺福韦艾拉芬胺
富马酸磷丙替诺福韦
替诺福韦艾拉酚胺富马酸
替诺福韦艾拉芬胺半富马酸
替诺福韦艾拉酚胺富马酸盐
替诺福韦艾拉酚胺富马酸半盐
替诺福韦-富马酸阿芬烯胺[ USAN ]
(S)-丙胺酸异丙酯2-{(S)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基半反丁烯二酸盐
| | 英文别名 | Anti-HIV
GS-7340 (hemifumarate)
Tenofovir Alafenamide fumarate
Tenofovir levamide amine fumarate
GS7340(Tenofovir Alafenamide Fumarate)
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
| | CAS | 1392275-56-7
| | EINECS | 805-448-8 | | 化学式 | C25H33N6O9P
| | 分子量 | 592.55 | | 溶解度 | DMSO | | 存储条件 | Keep in dark place,Sealed in dry,Room Temperature | | 产品用途 | 本品仅供科研，不得用于其它用途。 | | 体外研究 | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. | | 体内研究 | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) . |
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