替诺福韦艾拉酚胺富马酸盐 |
| 时间：2023-07-15 来源：化工号 作者：C25H33N6O9P |
替诺福韦艾拉芬胺富马酸磷丙替诺福韦替诺福韦艾拉酚胺富马酸替诺福韦艾拉芬胺半富马酸替诺福韦艾拉酚胺富马酸盐替诺福韦艾拉酚胺富马酸半盐替诺福韦-富马酸阿芬烯胺[ USAN ](S)-丙胺酸异丙酯2-{(S)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基半反丁烯二酸盐
| 中文名 | 替诺福韦艾拉酚胺富马酸盐
| | 英文名 | Tenofovir Alafenamide fumarate
| | 别名 | 替诺福韦艾拉芬胺
富马酸磷丙替诺福韦
替诺福韦艾拉酚胺富马酸
替诺福韦艾拉芬胺半富马酸
替诺福韦艾拉酚胺富马酸盐
替诺福韦艾拉酚胺富马酸半盐
替诺福韦-富马酸阿芬烯胺[ USAN ]
(S)-丙胺酸异丙酯2-{(S)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基半反丁烯二酸盐
| | 英文别名 | Anti-HIV
GS-7340 (hemifumarate)
Tenofovir Alafenamide fumarate
Tenofovir levamide amine fumarate
GS7340(Tenofovir Alafenamide Fumarate)
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
| | CAS | 1392275-56-7
| | EINECS | 805-448-8 | | 化学式 | C25H33N6O9P
| | 分子量 | 592.55 | | 溶解度 | DMSO | | 存储条件 | Keep in dark place,Sealed in dry,Room Temperature | | 产品用途 | 本品仅供科研，不得用于其它用途。 | | 体外研究 | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. | | 体内研究 | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) . |
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