石斛酚 |
| 时间：2023-07-15 来源：化工号 作者：C16H18O4 |
石斛酚石斛酚标准品
| 中文名 | 石斛酚
| | 英文名 | Gigantol(Dendrophenol)
| | 别名 | 石斛酚
石斛酚标准品
| | 英文别名 | Gigantic
Gigantol(Dendrophenol)
Phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol)
| | CAS | 67884-30-4
| | 化学式 | C16H18O4
| | 分子量 | 274.31 | | 密度 | 1.204±0.06 g/cm3(Predicted) | | 熔点 | 95-96°C | | 沸点 | 454.1±40.0 °C(Predicted) | | 溶解度 | DMSO : ≥ 100 mg/mL (364.55 mM) | | 酸度系数 | 9.63±0.10(Predicted) | | 存储条件 | 2-8℃ | | 外观 | 液体 | | 物化性质 | 类白色结晶体，易溶于甲醇、乙酸乙酯，几乎不溶于水，来源于金钗石斛。 | | MDL号 | MFCD11100326 | | 体外研究 | Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM. | | 体内研究 | LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats. | | 参考资料 展开查看 | 1. 张梅, 李春霞, 韦芳,等. 石斛酚对高糖诱导的人视网膜微血管内皮细胞的保护作用[J]. 国际眼科杂志, 2019, 19(02):40-44.
2. 范兆阳, 鲜文峰, 刘永喜,等. 石斛酚通过NF-κB/PRL-3通路抑制骨肉瘤细胞增殖,迁移和侵袭[J]. 中国肿瘤生物治疗杂志, 2019(10).
3. Yu, Shubin, et al. "Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells." BMC complementary and alternative medicine 18.1 (2018): 1-8.https://doi.org/10.1186/s12906-018-2108-x
4. [IF=3.659] Yu Shubin et al."Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells."Bmc Complem Altern M. 2018 Dec;18(1):1-8
5. [IF=5.037] Jiahui Huang et al."Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway."Life Sci. 2021 Jun;274:119354 |
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