丹參酸B鎂 |
| 时间：2023-07-18 来源：化工号 作者：C36H28MgO16 |
丹參酸B鎂丹参酚酸B甲酯丹参酸 B 镁盐
| 中文名 | 丹參酸B鎂
| | 英文名 | Magnesium lithospermate B
| | 别名 | 丹參酸B鎂
丹参酚酸B甲酯
丹参酸 B 镁盐
| | 英文别名 | Lithospermate B
Magnesium lithospermate B
Monomethyl lithospermate B
magnessium lithospermate B
magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
magnesium 2-({(2E)-3-[3-{[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl}oxy)-3-(3,4-dihydroxyphenyl)propanoate
Magnesium, (1-carboxy-2-(3,4-dihydroxyphenyl)ethyl 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylato(2-))-, (T-4-(2S-(2alpha,3beta(S*),4(E(S*)))))-
Magnesium, ((1R)-1-(carboxy-kappaO)-2-(3,4-dihydroxyphenyl)ethyl (2S,3S)-4-((1E)-3-((1R)-1-(carboxy-kappaO)-2-(3,4-dihydroxyphenyl)ethoxy)-3-(oxo-kappaO)-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylato(2-)-kappaO3')-, (T-4)-
| | CAS | 122021-74-3
| | 化学式 | C36H28MgO16
| | 分子量 | 740.90292 | | InChI | InChI=1/C36H30O16.Mg/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17;/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48);/q;+2/p-2/b10-5+ | | 沸点 | 1020.3°C at 760 mmHg | | 闪点 | 322.1°C | | 蒸汽压 | 0mmHg at 25°C | | 体外研究 | Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis. Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner. Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons. | | 体内研究 | Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats. Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models. Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats Dosage: 2, 8 mg/kg Administration: P.o. once daily for 16 days Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21. |
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