Lenampicillin Hydrochloride |
| 时间：2023-07-18 来源：化工号 作者：C21H23N3O7S |
| 中文名 | Lenampicillin Hydrochloride
| | 英文名 | Lenampicillin Hydrochloride
| | 别名 | 盐酸仑氨西林
化合物 T15734
| | 英文别名 | kb1585
kbt1585
kbt-1585
Lenampicillin Hydrochloride
LENAMPICILLIN HYDROCHLORIDE
-2-carboxylicacid,hydrochloride
ampicillin,(5-methyl-2-oxo-1,3-dioxolen-4-yl)methylester,hydrochloride
carbonicacid,cyclic1-(hydroxymethyl)-2-methylethyleneester,esterwith6-(2
(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-d-alpha-aminobenzylpenicillinatehyd
-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane
| | CAS | 80734-02-7
| | 化学式 | C21H23N3O7S
| | 分子量 | 461.49 | | 熔点 | 145° (dec) | | 存储条件 | 2-8℃ | | 体内研究 | Lenampicillin hydrochloride (KBT-1585)(oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver. |
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