Leonurine hydrochloride |
| 时间：2023-07-18 来源：化工号 作者：C14H21N3O5 |
| 中文名 | 盐酸益母草碱
| | 英文名 | Leonurine hydrochloride
| | 别名 | 盐酸益母草碱
益母草碱盐酸盐
盐酸益母草碱(标准品)
益母草碱盐酸盐,益母草碱
盐酸益母草碱(益母草碱盐酸盐,益母草碱)
LEONURINE HYDROCHLORIDE 盐酸益母草碱
3,5-二甲氧基-4-羟基-苯甲酸 (4-胍基)-1-丁酯一水合物盐酸盐
盐酸益母草碱(3,5-二甲氧基-4-羟基-苯甲酸 (4-胍基)-1-丁酯一水合物盐酸盐)
| | 英文别名 | SCM-198
Leonurine
24697-74-3
LEONURINE HCL
leonurine hydrochloride
Leonurine hydrochloride
4-Guanidino-1-butanol syringate
4-Guanidino-1-butanol Syringate
Syringic Acid d-Guanidinobutyl Ester
Leonurine 4-Guanidino-1-butanol syringate
[4-(4-Hydroxy-3,5-dimethoxybenzoyloxy)butyl]guanidine
4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester
4-Hydroxy-3,5-dimethoxybenzoic Acid d-Guanidinobutyl Ester
4-Carbamimidamidobutyl-4-hydroxy-3,5-dimethoxybenzolcarboxylat
4-[(diaminomethylidene)amino]butyl 4-hydroxy-3,5-dimethoxybenzoate
4-Hydroxy-3,5-dimethoxybenzoic Acid 4-[(Aminoiminomethyl)amino]butyl Ester
4-carbamimidamidobutyl 4-hydroxy-3,5-dimethoxybenzoate hydrochloride hydrate
benzoic acid, 4-hydroxy-3,5-dimethoxy-, 4-[(aminoiminomethyl)amino]butyl ester
4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride
| | CAS | 24697-74-3
| | EINECS | 683-174-6 | | 化学式 | C14H21N3O5
| | 分子量 | 311.33 | | InChI | InChI=1/C14H21N3O5.ClH.H2O/c1-20-10-7-9(8-11(21-2)12(10)18)13(19)22-6-4-3-5-17-14(15)16;;/h7-8,18H,3-6H2,1-2H3,(H4,15,16,17);1H;1H2 | | InChIKey | WNGSUWLDMZFYNZ-UHFFFAOYSA-N | | 密度 | 1.29±0.1 g/cm3(Predicted) | | 熔点 | 238 °C | | 沸点 | 496.7±55.0 °C(Predicted) | | 溶解度 | DMSO: soluble2mg/mL, clear (warmed) | | 酸度系数 | 8.26±0.25(Predicted) | | 存储条件 | Keep in dark place,Inert atmosphere,2-8°C | | 稳定性 | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | 外观 | powder | | 颜色 | white to beige | | 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于益母草。 | | MDL号 | MFCD09839432 | | 体外研究 | Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner. | | 体内研究 | Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model. | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 3 | | 海关编号 | 29399990 | | 参考资料 展开查看 | 1. 秦美蓉, 王平, 王晓炜,等. 盐酸益母草碱和盐酸水苏碱对大鼠离体子宫收缩的影响[J]. 今日药学, 2013(07):410-412.
2. 仇正英,李刚,辛蕊华,崔东安,张凯,王磊,张康,李建喜.注射型盐酸益母草碱穴位埋植凝胶的制备及其含量测定[J].中兽医医药杂志,2020,39(05):29-34.
3. Wu, Haichong, et al. "Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis." International immunopharmacology 61 (2018): 156-161.https://doi.org/10.1016/j.intimp.2018.06.002
4. [IF=3.943] Haichong Wu et al."Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis."Int Immunopharmacol. 2018 Aug;61:156
5. [IF=4.36] Shi-Jie Bi et al."Network pharmacology-based study on immunomodulatory mechanism of danggui-yimucao herb pair for the treatment of RU486-induced abortion."J Ethnopharmacol. 2022 Jan;282:114609
6. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
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