Nifenalol HCl |
| 时间：2023-07-18 来源：化工号 作者：C11H17ClN2O3 |
| 中文名 | Nifenalol HCl
| | 英文名 | 2-(Isopropylamino)-1-(p-nitrophenyl)ethanol hydrochloride
| | 别名 | 硝苯洛尔盐酸盐
1-(4-硝基苯基)-1-羟基-2-异丙基氨基乙烷盐酸盐
| | 英文别名 | INPEA
Nifenalol HCl
Nifenalol (hydrochloride)
Nifenalol monohydrochloride
2-(Isopropylamino)-1-(p-nitrophenyl)ethanol hydrochloride
1-(4-Nitrophenyl)-1-hydroxy-2-isopropylaminoethane hydrochloride
()-alpha-[[isopropylamino]methyl]-4-nitrobenzylalcoholmonohydrochloride
(±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride
Benzenemethanol, α-[[(1-methylethyl)amino]methyl]-4-nitro-, monohydrochloride (9CI)
| | CAS | 5704-60-9
| | EINECS | 227-194-1 | | 化学式 | C11H17ClN2O3
| | 分子量 | 260.72 | | 熔点 | 181° | | 溶解度 | Soluble in DMSO | | 存储条件 | -20℃ | | 靶点 | β-adrenergic receptor | | 参考资料 展开查看 | 1: Rabast U, Kasper H, Schönborn J, Knechtel B. [Blood glucose concentration and insulin activity in serum after administration of the beta receptor blockader nifenalol-HC1 (INPEA). Studies in metabolically healthy people and diabetics]. Ther Ggw. 1977 Jun;116(6):1162-74. German. PubMed PMID: 578017.
2: Nishimura T, Kita S, Abiko Y. Effects of 1-(4-nitrophenyl)-2-isopropylaminoethanol (INPEA) and propranolol and their dextro-isomers on hemodynamic and metabolic responses to isoproterenol in dogs. J Pharmacol Exp Ther. 1983 Aug;226(2):595-602. PubMed PMID: 6688273.
3: Hasslacher C, Wahl P, Riemer G. [Influence of the beta-receptor blocker nifenalol on insulin secretion in normal subjects and diabetic patients (author's transl)]. Arzneimittelforschung. 1977 Feb;27(2):426-9. German. PubMed PMID: 577165.
4: Ichiyama M, Sada S, Takahashi Y, Sada H, Ban T. Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):297-304. PubMed PMID: 2872598. |
|
|
|
|
