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3-氧代丁酸钠盐

时间:2023-07-18  来源:化工号   作者:C4H6O3
中文名 3-氧代丁酸钠盐
英文名 Acetoacetic acid sodium salt
别名 乙酰乙酸钠
乙酰基乙酸钠盐
3-氧代丁酸钠盐
英文别名 Arbidol Impurity 45
Sodium 3-oxobutanoate
sodium 2-acetoxyacetate
ACETYLACETICACID,SODIUMSALT
Acetoacetic acid sodium salt
3-Oxobutyric acid sodium salt
3-Oxobutanoic acid sodium salt
Sodium Acetoacetate DISCONTINUED. Please see L469065.
CAS 623-58-5
化学式 C4H6O3
分子量 124.07
沸点 52 °C(Press: 5 Torr)
存储条件 Room Temprature
物化性质 生物活性 Acetoacetic acid sodium salt 是一种非酯化脂肪酸代谢物,参与人类糖尿病的发展。Acetoacetic acid sodium salt 诱导氧化应激,抑制牛肝细胞中极低密度脂蛋白的组装。
体外研究 Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.
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