羟吡酮 |
| 时间：2023-07-15 来源：化工号 作者：C16H30N2O3 |
| 中文名 | 羟吡酮
| | 英文名 | Piroctone Oleamine
| | 别名 | 去屑剂
羟吡酮
罗酮奥拉明
吡罗克酮乙醇铵
吡啶酮乙醇胺盐
吡罗克酮 乙醇胺盐
吡啶酮乙醇胺盐(去屑剂OCTO)
1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐
| | 英文别名 | Octopirox
octopiroxolamine
piroctone olamine
Piroctone Oleamine
Pyridine-amino ethanol
Hydroxyl pyrazole ketones
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine
4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
| | CAS | 68890-66-4
| | EINECS | 272-574-2 | | 化学式 | C16H30N2O3
| | 分子量 | 298.43 | | InChI | InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2 | | InChIKey | BTSZTGGZJQFALU-UHFFFAOYSA-N | | 密度 | 1.1[at 20℃] | | 熔点 | 134.0 to 138.0 °C | | 沸点 | 135-235℃[at 101 325 Pa] | | 闪点 | 161.9°C | | 水溶性 | 400-50000mg/L at 20-25℃ | | 蒸汽压 | 0-0Pa at 20-25℃ | | 溶解度 | Chloroform (Slightly, Sonicated), Methanol (Slightly) | | 酸度系数 | 5.9-7.4[at 20 ℃] | | 存储条件 | Inert atmosphere,2-8°C | | 外观 | neat | | 颜色 | White to Off-White | | Merck | 14,7502 | | MDL号 | MFCD01690792 | | 体外研究 | Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL). | | 体内研究 | This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05). | | WGK Germany | 2 | | RTECS | UU7786150 | | 海关编号 | 2933399090 | | 上游原料 | 3,5,5-三甲基己酰氯 3,3-二甲基丙烯酸甲酯 |
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