130-16-5 |
| 时间：2023-07-15 来源：化工号 作者：C9H6ClNO |
| 中文名 | 5-氯-8-羟基喹啉
| | 英文名 | 5-Chloro-8-hydroxyquinoline
| | 别名 | 氯羟喹
5-氯-8-喹啉醇
5-氯-8-羟基喹啉
氯碘羟喹杂质A(EP)
5-氯-8-羟基喹啉氯羟喹
氯碘羟喹EP杂质A(氯羟喹啉)
| | 英文别名 | cloxiquine
5-CHLOROOXINE
5-CHLOROQUINOPHENOL
5-chloro-8-quinolino
5-Chloro-8-quinolinol
5-CHLORO-8-QUINOLINOL
5-chloroquinolin-8-ol
5-Chloro-8-oxyquinoline
Clioquinol EP Impurity A
5-CHLORO-8-HYDROXYQUINOLINE
5-Chloro-8-hydroxyquinoline
| | CAS | 130-16-5
| | EINECS | 204-978-1 | | 化学式 | C9H6ClNO
| | 分子量 | 179.6 | | InChI | InChI=1/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H | | InChIKey | RWPWQYXFGFYJBA-UHFFFAOYSA-N | | 密度 | 1.2364 (rough estimate) | | 熔点 | 122-124°C(lit.) | | 沸点 | 348.7±22.0 °C(Predicted) | | 闪点 | 164.7°C | | 蒸汽压 | 0.003Pa at 25℃ | | 溶解度 | 0.019g/l (experimental) | | 折射率 | 1.5330 (estimate) | | 酸度系数 | 3.77±0.10(Predicted) | | 存储条件 | Sealed in dry,Room Temperature | | 敏感性 | Light Sensitive | | 外观 | Powder | | 颜色 | Light green to gray | | Merck | 14,2422 | | BRN | 5289 | | 物化性质 | 熔点 121-126°C | | 产品用途 | 用于有机合成 | | MDL号 | MFCD00006788 | | 体外研究 | Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis . Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner. Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells. Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells. | | 体内研究 | Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model. Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model. | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36 - 穿戴适当的防护服。
S24/25 - 避免与皮肤和眼睛接触。
| | WGK Germany | 3 | | RTECS | VC4590000 | | TSCA | Yes | | 海关编号 | 29334990 | | 上游原料 | 8-羟基喹啉 | | 下游产品 | 8-羟基-1,2,3,4-四氢喹啉 |
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