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71751-41-2

时间：2023-07-15 来源：化工号作者：C₄₉H₇₄O₁₄

阿灵

克螨灵

中文名	阿维菌素
英文名	Abamectin
别名	阿灵克螨灵杀虫素阿巴汀齐螨素白螨净爱弗菌素辛阿乳油阿维菌素阿佛菌素阿维菌素精品阿维菌素原料药依维菌素杂质1 阿维菌素 B1a 伊维菌素EP杂质A 甲醇中阿维菌素标准溶液
英文别名	Avid Zephyr Affirm Acimic Abacide Dynamec Agri-Mek Abamectin Dynamec(R) Bermectine Abamectine Avermectin Avermectins AGRI-MEK(R) ABERMECTINS Avermectin B Abamectin soL abamectin B1a Avermectin B1 avermectin B1b avermectin B1a avermectin b1a Antibiotic C-076B1a Purity of AbaMectin 5-O-DemethylAvermectin A1a 5-o-demethyl-avermectin a1 AverMectin A1a,5-O-deMethyl- AbaMectin (AverMectin B1)(FDA) Mixture of abamectin B1a and B1b Abamectin Solution in Acetonitrile AverMectin B1a-AverMectin B1b Mixt. Mixture of Avermectin B1a and Avermectin B1b Ivermectin Impurity 1(Ivermectin EP Impurity A) 5-O-demethylavermectin A1a (i) mixture with 5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)avermectin A1a (ii) (5'S,6S,6'R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside (2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
CAS	71751-41-2 73989-17-0 65195-55-3
EINECS	200-096-6
化学式	C49H74O14
分子量	887.11
InChI	InChI=1/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15-,32-14-/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChIKey	GVWIWZFXCGTSLL-MSTMYQEVSA-N
密度	1.16
熔点	150-155°C
沸点	717.52°C (rough estimate)
比旋光度	D +55.7 ±2° (c = 0.87 in CHCl3)
闪点	150°C
水溶性	0.007-0.01 mg l-1 (20 °C)
蒸汽压	-7 Pa
溶解度	Soluble in DMSO
折射率	1.6130 (estimate)
酸度系数	12.42±0.70(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
外观	neat
Merck	13,2
物化性质	外观为淡黄色至白色结晶粉末，无味。m.p.155～157℃，蒸气压2×10-7Pa，相对密度1.16(21℃)。21℃时溶解度为：甲苯350g/L、丙酮100g/L、异丙醇70g/L、氯仿25g/L、乙醇20g/L、甲醇19.5g/L、环己烷6g/L、煤油0.5g/L、水10μg/L。分配系数9.9×103。正常条件下稳定，pH值5～9时不会水解。
产品用途	对线虫、昆虫和螨虫均有驱杀作用，用于治疗畜禽的线虫病、螨和寄生性昆虫病
MDL号	MFCD01769550
体外研究	[ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.
体内研究	Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.
危险品标志	T+ - 极高毒性物品 N - 危害环境的物品
风险术语	R20 - 吸入有害。 R28 - 吞食有极高毒性。 R50 - 对水生生物有极高毒性。
安全术语	S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S60 - 该物质及其容器须作为危险性废料处置。 S61 - 避免释放至环境中。参考特别说明/安全数据说明书。
危险品运输编号	2588
WGK Germany	3
RTECS	CL1203000
Hazard Class	6.1(a)
Packing Group	II
上游原料	淀粉无水葡萄糖淀粉
下游产品	阿维菌素乳油
参考资料展开查看	1. 陈慧妍, 季祥. 液相色谱-串联质谱法测定梨果中阿维菌素残留量[J]. 农家参谋, 2018, No.570(01):190-190. 2. 权云帆, 王佩, 王昊,等. 红树林来源真菌Xylaria sp.HNWSW-2异香豆素类次生代谢产物及其生物活性的研究[J]. 热带作物学报, 2019(8). 3. 张振威, 赵清泉, 郝昕,等. 阿维菌素和甲维盐对舞毒蛾幼虫的毒力及解毒酶活性的影响. 4. Zhang, Xuan, et al. "Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects." Pharmacological research 156 (2020): 104763. 5. [IF=7.658] Xuan Zhang et al."Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects."Pharmacol Res. 2020 Jun;156:104763 6. [IF=4.714] Xue Yin et al.Identification and pharmacological characterization of histamine-gated chloride channels in the fall armyworm, Spodoptera frugiperda.Insect Biochem Molec. 2022 Jan;140:103698

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