71751-41-2 |
| 时间：2023-07-15 来源：化工号 作者：C49H74O14 |
| 中文名 | 阿维菌素
| | 英文名 | Abamectin
| | 别名 | 阿灵
克螨灵
杀虫素
阿巴汀
齐螨素
白螨净
爱弗菌素
辛阿乳油
阿维菌素
阿佛菌素
阿维菌素精品
阿维菌素原料药
依维菌素杂质1
阿维菌素 B1a
伊维菌素EP杂质A
甲醇中阿维菌素标准溶液
| | 英文别名 | Avid
Zephyr
Affirm
Acimic
Abacide
Dynamec
Agri-Mek
Abamectin
Dynamec(R)
Bermectine
Abamectine
Avermectin
Avermectins
AGRI-MEK(R)
ABERMECTINS
Avermectin B
Abamectin soL
abamectin B1a
Avermectin B1
avermectin B1b
avermectin B1a
avermectin b1a
Antibiotic C-076B1a
Purity of AbaMectin
5-O-DemethylAvermectin A1a
5-o-demethyl-avermectin a1
AverMectin A1a,5-O-deMethyl-
AbaMectin (AverMectin B1)(FDA)
Mixture of abamectin B1a and B1b
Abamectin Solution in Acetonitrile
AverMectin B1a-AverMectin B1b Mixt.
Mixture of Avermectin B1a and Avermectin B1b
Ivermectin Impurity 1(Ivermectin EP Impurity A)
5-O-demethylavermectin A1a (i) mixture with 5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)avermectin A1a (ii)
(5'S,6S,6'R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside
(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
| | CAS | 71751-41-2
73989-17-0
65195-55-3
| | EINECS | 200-096-6 | | 化学式 | C49H74O14
| | 分子量 | 887.11 | | InChI | InChI=1/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15-,32-14-/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1 | | InChIKey | GVWIWZFXCGTSLL-MSTMYQEVSA-N | | 密度 | 1.16 | | 熔点 | 150-155°C | | 沸点 | 717.52°C (rough estimate) | | 比旋光度 | D +55.7 ±2° (c = 0.87 in CHCl3) | | 闪点 | 150°C | | 水溶性 | 0.007-0.01 mg l-1 (20 °C) | | 蒸汽压 | -7 Pa | | 溶解度 | Soluble in DMSO | | 折射率 | 1.6130 (estimate) | | 酸度系数 | 12.42±0.70(Predicted) | | 存储条件 | Sealed in dry,Store in freezer, under -20°C | | 外观 | neat | | Merck | 13,2 | | 物化性质 | 外观为淡黄色至白色结晶粉末，无味。m.p.155～157℃，蒸气压2×10-7Pa，相对密度1.16(21℃)。21℃时溶解度为：甲苯350g/L、丙酮100g/L、异丙醇70g/L、氯仿25g/L、乙醇20g/L、甲醇19.5g/L、环己烷6g/L、煤油0.5g/L、水10μg/L。分配系数9.9×103。正常条件下稳定，pH值5～9时不会水解。 | | 产品用途 | 对线虫、昆虫和螨虫均有驱杀作用，用于治疗畜禽的线虫病、螨和寄生性昆虫病 | | MDL号 | MFCD01769550 | | 体外研究 | [ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations. | | 体内研究 | Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms. | | 危险品标志 | T+ - 极高毒性物品
N - 危害环境的物品
| | 风险术语 | R20 - 吸入有害。
R28 - 吞食有极高毒性。
R50 - 对水生生物有极高毒性。
| | 安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。
S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
S60 - 该物质及其容器须作为危险性废料处置。
S61 - 避免释放至环境中。参考特别说明/安全数据说明书。
| | 危险品运输编号 | 2588 | | WGK Germany | 3 | | RTECS | CL1203000 | | Hazard Class | 6.1(a) | | Packing Group | II | | 上游原料 | 淀粉 无水葡萄糖 淀粉 | | 下游产品 | 阿维菌素乳油 | | 参考资料 展开查看 | 1. 陈慧妍, 季祥. 液相色谱-串联质谱法测定梨果中阿维菌素残留量[J]. 农家参谋, 2018, No.570(01):190-190.
2. 权云帆, 王佩, 王昊,等. 红树林来源真菌Xylaria sp.HNWSW-2异香豆素类次生代谢产物及其生物活性的研究[J]. 热带作物学报, 2019(8).
3. 张振威, 赵清泉, 郝昕,等. 阿维菌素和甲维盐对舞毒蛾幼虫的毒力及 解毒酶活性的影响.
4. Zhang, Xuan, et al. "Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects." Pharmacological research 156 (2020): 104763.
5. [IF=7.658] Xuan Zhang et al."Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects."Pharmacol Res. 2020 Jun;156:104763
6. [IF=4.714] Xue Yin et al.Identification and pharmacological characterization of histamine-gated chloride channels in the fall armyworm, Spodoptera frugiperda.Insect Biochem Molec. 2022 Jan;140:103698 |
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