NSC 663284 |
| 时间：2023-07-15 来源：化工号 作者：C15H16ClN3O3 |
化合物 T16357
| 中文名 | NSC 663284
| | 英文名 | NSC 663284
| | 别名 | 化合物 T16357
| | 英文别名 | NSC 663284
CDC25 Phosphatase Inhibitor II, NSC 663284
5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-
| | CAS | 383907-43-5
| | 化学式 | C15H16ClN3O3
| | 分子量 | 321.76 | | 密度 | 1.41±0.1 g/cm3(Predicted) | | 沸点 | 478.8±45.0 °C(Predicted) | | 溶解度 | DMSO: 16mg/mL | | 酸度系数 | 6.79±0.10(Predicted) | | 存储条件 | 2-8°C | | 稳定性 | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | 敏感性 | Light Sensitive | | 外观 | solid | | 颜色 | red | | 体外研究 | NSC 663284 (3-100μM; 48 hours) has a mean IC 50 value in the NCI 60 Cell human tumor panel of 1.5 ± 0.6 μM, has IC 50 values of 0.2 μM in human breast cancer MDA-MB-435 and MDA-N cells, has an IC 50 value of 1.7 μM in human breast MCF-7 cells in culture.NSC 663284 has relative IC 50 values for Cdc25B2 (IC 50 =0.21 μM) are 20- and 450-fold lower than for VHR (IC 50 =4.0 μM) or PTP1B (IC 50 >4.0 μM), respectively. | | 体内研究 | NSC 663284 (intravenous injection; 2, 3, and 5mg/kg) inhibits the growth of subcutaneous human colon HT29 xenografts in SCID mice. After a single dose of 5 mg/kg, NSC 663284 is not detectable in plasma or tissues beyond 5 min. Following NSC 663284 treatment of tumor-bearing SCID mice, reduces glutathione concentrations in HT29 tumor are decreased to a greater extent and remained decreased for longer than the reduced glutathione concentrations in liver and kidneys. | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | 26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
| | WGK Germany | 3 |
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