GS 7340 富马酸盐 |
| 时间：2023-07-15 来源：化工号 作者：C25H33N6O9P |
GS7340单盐富马酸GS-7340泰诺福韦艾拉酚胺半盐GS 7340 富马酸盐泰诺福韦艾拉酚胺富马酸盐替诺福韦艾拉酚胺富马酸单盐替诺福韦艾拉酚胺富马酸盐[单盐]
| 中文名 | GS 7340 富马酸盐
| | 英文名 | GS-7340 Fumarate
| | 别名 | GS7340单盐
富马酸GS-7340
泰诺福韦艾拉酚胺半盐
GS 7340 富马酸盐
泰诺福韦艾拉酚胺富马酸盐
替诺福韦艾拉酚胺富马酸单盐
替诺福韦艾拉酚胺富马酸盐[单盐]
| | 英文别名 | vemlidy
GS-7340 Fumarate
GS-7340 (fuMarate)
Tenofovir alafenamide-19
tenofovir alafenamide fumarate (TAF)
| | CAS | 379270-38-9
| | EINECS | 223-388-5 | | 化学式 | C25H33N6O9P
| | 分子量 | 592.55 | | 溶解度 | DMSO: ≥ 36 mg/mL | | 存储条件 | under inert gas (nitrogen or Argon) at 2-8°C | | 体外研究 | Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. | | 体内研究 | Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF). |
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