1188-38-1 |
| 时间：2023-07-15 来源：化工号 作者：C6H10N2O5 |
氨甲酰谷氨酸N-氨甲酰基谷氨酸N-氨基甲酰谷氨酸N-氨甲酰-L-谷氨酸N-氨基甲酰-L-谷氨酸N-氨基甲酰基-L-谷氨酸N-氨基甲酰谷氨酸(NCG)N-氨基甲酰-L-谷氨酸(N-氨甲酰-L-谷氨酸)
| 中文名 | N-氨基甲酰-L-谷氨酸
| | 英文名 | N-carbamyl-L-glutamic acid
| | 别名 | 氨甲酰谷氨酸
N-氨甲酰基谷氨酸
N-氨基甲酰谷氨酸
N-氨甲酰-L-谷氨酸
N-氨基甲酰-L-谷氨酸
N-氨基甲酰基-L-谷氨酸
N-氨基甲酰谷氨酸(NCG)
N-氨基甲酰-L-谷氨酸(N-氨甲酰-L-谷氨酸)
| | 英文别名 | NCG
Carbaglu
N-Cbm-Glu-OH
Carglumic acid
UNII-5L0HB4V1EW
Ureidoglutaric acid
N-Carbamylglutamate
Carglumic acid [INN]
carbamylglutamicacid
N-Carbamyl-L-glutamic
Carbamylglutamic acid
N-Carbamyl-L-glutamate
carbamino-l-glutamicacid
Carbamino-L-glutamic acid
L-N-Carbamoylglutamic acid
N-carbamyl-L-glutamic acid
N-CARBAMYL-L-GLUTAMIC ACID
N-Carbamoyl-L-glutamic acid
NCG,N-carbamyl-L-glutamic acid
N-(aminocarbonyl)-L-Glutamic acid
L-Glutamic acid, N-(aminocarbonyl)-
Glutamic acid, N-carbamoyl-, L- (8CI)
N-(Aminocarbonyl)-L-Glutamic Acid(Carglumic Acid)
| | CAS | 1188-38-1
| | EINECS | 601-569-3 | | 化学式 | C6H10N2O5
| | 分子量 | 190.15 | | InChI | InChI=1/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1 | | 密度 | 1.499±0.06 g/cm3(Predicted) | | 熔点 | 174° | | 沸点 | 438.1±45.0 °C(Predicted) | | 闪点 | 218.8°C | | 蒸汽压 | 6.7E-09mmHg at 25°C | | 溶解度 | DMSO (Slightly), Methanol (Slightly, Sonicated) | | 折射率 | 1.544 | | 酸度系数 | 3.71±0.10(Predicted) | | 存储条件 | Keep in dark place,Inert atmosphere,2-8°C | | 外观 | Solid | | 颜色 | White to Off-White | | 产品用途 | 本品仅供科研，不得用于其它用途。 | | 体外研究 | Carglumic acid suppresses cell viability in the pancreatic ductal adenocarcinoma cell lines, triple-negative breast cancer cell lines, hepatoma cell lines, and human non-small cell lung carcinoma cell lines in a dose-dependent manner. The 50% inhibitory concentration (IC 50 ) of Carglumic acid against those cell lines is between 5 and 7.5 mM. The results show that Carglumic acid does not induce complete cell cycle arrest. Instead, there are more sub-G1 cells among Carglumic acid-treated AsPC1 and MDA-MB-231 cells than among untreated cells. In AsPC1 and HPDE-E6E7 cells, the IC 50 s of Carglumic acid are 5 mM and over 10 mM, respectively . In MDA-MB-231 and MCF-12A cells, the IC 50 s of Carglumic acid are 5 mM and 6 mM, respectively. | | 体内研究 | The results show that Carglumic acid, but not the vehicle control, markedly inhibits tumor growth. In the orthotopic pancreatic cancer model, tumor growth inhibition by Carglumic acid on day 21 is 80% (P<0.01). In the orthotopic triple-negative breast cancer model, tumor growth inhibition by Carglumic acid on day 20 is 82% (P<0.01). These results indicate that Carglumic acid suppresses tumor growth in pancreatic cancer and triple-negative breast cancer. On day 20, mean tumor growth inhibition in orally and intravenously treated mice is 55% and 93%, respectively, relative to untreated mice (P<0.01). | | 危险品标志 | Xi - 刺激性物品
| | 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
| | 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36/37 - 穿戴适当的防护服和手套。
| | WGK Germany | 3 | | RTECS | LZ9870000 | | 海关编号 | 2924190002 | | 上游原料 | 3-酰脲丙酸 氰酸钠 |
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